Frontiers of Physics in China

, Volume 4, Issue 4, pp 469–480

Advances in surface plasmon resonance-based high throughput biochips

  • San-jun Zhang (张三军)
  • Lotfi Berguiga
  • Juan Elezgaray
  • Nicolas Hugo
  • Wen-xue Li (李文雪)
  • Thibault Roland
  • He-ping Zeng (曾和平)
  • Francoise Argoul
Review Article


This article reviews our recent advances in surface plasmon resonance (SPR) based biochips. It includes four issues, which are the preparation and characterization of high quality gold film, the preparation and characterization of self-assembled monolayer (SAM), dynamics of DNA adsorption on SAMs, and SPR-based microscopies. Numerous topics related to SPR, such as, the modeling of SPR by transmission matrix, effective medium theory, applications of SPR in biology, and SPR-based novel microscopies, are discussed. A novel electrochemical technique, which is extremely useful for the preparation and characterization of high quality SAMs, is also discussed.


surface plasmon resonance effective medium theory self-assembled monolayer electrochemical impedance spectroscopy atomic force microscopy SPR-based microscopy 

PACS numbers

42.25.Bs 42.30.Va 68.35.-p 68.37.Ps 87.80.-y 87.85.dh 87.85.Rs 


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Copyright information

© Higher Education Press and Springer Berlin Heidelberg 2009

Authors and Affiliations

  • San-jun Zhang (张三军)
    • 1
    • 2
  • Lotfi Berguiga
    • 1
  • Juan Elezgaray
    • 3
  • Nicolas Hugo
    • 1
  • Wen-xue Li (李文雪)
    • 2
  • Thibault Roland
    • 1
  • He-ping Zeng (曾和平)
    • 2
  • Francoise Argoul
    • 1
  1. 1.Laboratoire Joliot Curie USR3010, Laboratoire de Physique UMR5672CNRS Ecole Normale Supérieure de LyonLyonFrance
  2. 2.Key Laboratory of Optical and Magnetic Resonance Spectroscopy, and Department of PhysicsEast China Normal UniversityShanghaiChina
  3. 3.UMR 5248CNRS-Université Bordeaux 1-ENITAB, IECBPESSACFrance
  4. 4.Laboratoire de Photonique Quantique et MoléculaireEcole Normale Supérieure de CachanCachanFrance

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