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Frontiers of Chemistry in China

, Volume 5, Issue 4, pp 357–422 | Cite as

A golden phoenix arising from the herbal nest — A review and reflection on the study of antimalarial drug Qinghaosu

  • Ying Li
  • Yu-Lin Wu
Feature Article

Abstract

Qinghaosu (QHS) and its derivatives are a new generation of antimalarial drugs characterized by fast action, high efficacy, and good tolerance. This feature article states the discovery of QHS from traditional Chinese medicine qinghao (Artemisia annua L.) and reviews the progress during the past four decades in the research of phytochemistry of A. annua, chemical reactions and biotransformation of QHS, chemical synthesis and biosynthesis of QHS, synthesis and antimalarial activity of QHS derivatives and analogs, pharmacological studies, clinical application, and the antimalarial mechanism. Undoubtedly, QHS is an example of the value of traditional Chinese medicine in modern medicinal research.

Keywords

Malaria Artemisinin Antimalarial Drug Artesunate Artemisinin Combination Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Department of Medicinal Chemistry, Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina
  2. 2.State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghaiChina

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