Frontiers of Chemistry in China

, Volume 4, Issue 3, pp 299–306

Chiral ruthenium-SDPs/diamine complexes-catalyzed enantioselective hydrogenation of α-alkyl arylacetones via dynamic kinetic resolution

  • Jianhua Xie
  • Weiling Kong
  • Xiaocheng Wang
  • Wenju Bai
  • Lixin Wang
  • Qilin Zhou
Research Article

DOI: 10.1007/s11458-009-0093-9

Cite this article as:
Xie, J., Kong, W., Wang, X. et al. Front. Chem. China (2009) 4: 299. doi:10.1007/s11458-009-0093-9

Abstract

The asymmetric hydrogenation of the conformationally flexible racemic α-substituted acyclic dialkyl ketones via dynamic kinetic resolution (DKR) has been developed by using Ru-SDPs/diamine catalysts. Chiral alcohols were produced in high yields with good to excellent enantioselectivities (85%–97% ee) and diastereoselectivities (up to 97:3). This hydrogenation reaction provided a new approach to the synthesis of the key intermediate of J-104118.

Keywords

asymmetric hydrogenation arylacetones catalysis diphosphine diamine ruthenium 

Copyright information

© Higher Education Press and Springer-Verlag GmbH 2009

Authors and Affiliations

  • Jianhua Xie
    • 1
  • Weiling Kong
    • 1
  • Xiaocheng Wang
    • 1
  • Wenju Bai
    • 1
  • Lixin Wang
    • 1
  • Qilin Zhou
    • 1
  1. 1.State Key Laboratory and Institute of Elemento-organic ChemistryNankai UniversityTianjinChina

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