Frontiers of Chemistry in China

, Volume 1, Issue 2, pp 211–216 | Cite as

Preparation, characterization and properties studies of quinine-imprinted polymer in the aqueous phase

  • He Jianfeng 
  • Liu Lan 
  • Yang Guilan 
  • Deng Qinying 
Research Article


The uniform-sized spherical molecularly imprinted polymers were successfully prepared through molecular imprinting technology by two-step seed swelling and mini-emulsion polymerization in the aqueous condition using quinine as template molecules and methacrylic acid (MAA) as functional monomer. The polymers were characterized by IR spectra, thermal-weight analysis, scanning electron microscope and laser particle size analysis. The properties of imprinted polymers were investigated in different organic phases and aqueous media. In the organic media, results suggested that polar interactions (hydrogen bonding, ionic interactions) between acidic monomer/polymer and template molecules are mainly responsible for the binding and recognition; whereas in the aqueous medium, a considerable recognition effect was also obtained where the ionic (electrostatic) interaction and hydrophobic interaction play an important role. The experiments of binding different substrates indicated that the MIPs possessed an excellent rebinding ability and inherent selectivity to quinine.


template two-step seed swelling mini-emulsion polymerization molecular imprinting technology 


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Copyright information

© Higher Education Press and Springer-Verlag 2006

Authors and Affiliations

  1. 1.College of PharmacyGuangzhou University of Traditional Chinese medicineGuangzhouChina
  2. 2.School of Chemistry and Chemical EngineeringSun Yat-san UniversityGuangzhouChina

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