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Chinese Science Bulletin

, Volume 58, Issue 21, pp 2570–2575 | Cite as

Star-shaped conjugated oligoelectrolyte for bioimaging in living cells

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Article Special Issue: Nono-Biomedical Optoelectronic Materials and Devices
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Abstract

A new star-shaped oligoelectrolyte (TEFCOONa) with triphenylamine as the core, acetylene as linkage and anionic fluorenes as arms was obtained and used for direct imaging in living PANC-1 cells. Because of the hydrophobic conjugated groups of the oligoelectrolyte, TEFCOONa can form nanospheres with an average diameter of ∼75 nm in 10 mmol/L PBS. These nanospheres possess a relatively high absolute quantum yield (16.5% in PBS), low cytotoxicity and can penetrate into the nucleus through the cytoplasm, which is essential for living cellular imaging. Collectively, these results validate our rational design of conjugated oligoelectrolyte and even hyper branched polymers-copolyelectrolyte as effective nanovectors for bioimaging and other clinical applications.

Keywords

star-shaped oligoelectrolyte absolute quantum yield nanospheres bioimaging 
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Copyright information

© The Author(s) 2013

Authors and Affiliations

  1. 1.Key Laboratory for Organic Electronics & Information Displays (KLOEID) and Institute of Advanced Materials (IAM)Nanjing University of Posts & Telecommunications (NJUPT)NanjingChina

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