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Chinese Science Bulletin

, Volume 57, Issue 1, pp 48–53 | Cite as

CD8+ T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model

  • YaJun Yang
  • XiaoZhu Li
  • YaoHe Wang
  • ShengDian WangEmail author
Open Access
Invited Article Immunology

Abstract

The role of anti-tumor immune responses in oncolytic adenoviral therapy has not been well studied due to lack of efficacious tumor model in immunocompetent mice. Here, we evaluated the contributions of immune components to the therapeutic effects of oncolytic adenoviruse in an immunocompetent murine tumor model permissive for infection and replication of adenovirus. We found that CD8+ T cells were critical mediator for antitumor efficacy by oncolytic adenovirus. Intratumoral viral therapy induced intensive infiltration of CD8+ T cells in tumor, increased tumor-specific IFN-γ (interferon-γ) production and CTL (cytotoxic T lymphocyte) activity of lymphocytes, and generated a long-term tumor-specific immune memory. Boosting CD8+ T cell responses by agonistic anti-4-1BB (cluster differentiation 137, CD137) antibody showed synergistic anticancer effects with oncolytic virotherapy. Our results provide insight into antitumor mechanisms of oncolytic adenovirus in addition to their direct oncolytic effect.

Keywords

oncolytic adenoviral therapy CD8+ T cells immune responses anti-4-1BB antibody 

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Copyright information

© The Author(s) 2012

Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.

Authors and Affiliations

  • YaJun Yang
    • 1
  • XiaoZhu Li
    • 1
  • YaoHe Wang
    • 2
    • 3
  • ShengDian Wang
    • 1
    Email author
  1. 1.Key Laboratory of Infection and Immunity, Institute of BiophysicsChinese Academy of SciencesBeijingChina
  2. 2.Sino-British Research Center for Molecular OncologyZhengzhou UniversityZhengzhouChina
  3. 3.Center for Molecular Oncology, Barts Cancer InstituteQueen Mary University of LondonLondonUK

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