Chinese Science Bulletin

, Volume 52, Issue 19, pp 2649–2656

Scanning for signatures of geographically restricted selection based on population genomics analysis

  • Deng LiBin 
  • Tang XiaoLi 
  • Kang Jian 
  • Wang QingYun 
  • Zeng ChangQing 
Articles Genetics

DOI: 10.1007/s11434-007-0400-0

Cite this article as:
Deng, L., Tang, X., Kang, J. et al. CHINESE SCI BULL (2007) 52: 2649. doi:10.1007/s11434-007-0400-0

Abstract

Natural selection, as the driving force of human evolution, has direct impact on population differentiation. However, it is still unclear to what extent the genetic differentiation has been caused by natural selection. To explore this question, we performed a genome-wide scan with single nucleotide polymorphism (SNP) data from the International HapMap Project. Single locus FST analysis was applied to assess the frequency difference among populations in autosomes. Based on the empirical distribution of FST, we identified 12669 SNPs correlating to population differentiation and 1853 candidate genes subjected to geographic restricted natural selection. Further interpretation of gene ontogeny revealed 121 categories of biological process with the enrichments of candidate genes. Our results suggest that natural selection may play an important role in human population differentiation. In addition, our analysis provides new clues as well as research methods for our understanding of population differentiation and natural selection.

Keywords

natural selection HapMap Project single nucleotide polymorphism population genomics gene ontology 

Copyright information

© Science in China Press 2007

Authors and Affiliations

  • Deng LiBin 
    • 1
    • 2
  • Tang XiaoLi 
    • 1
  • Kang Jian 
    • 3
  • Wang QingYun 
    • 4
  • Zeng ChangQing 
    • 1
  1. 1.Beijing Institute of GenomicsChinese Academy of SciencesBeijingChina
  2. 2.Graduate University of Chinese Academy of SciencesBeijingChina
  3. 3.Department of Mathematical Sciences, School of ScienceTsinghua UniversityBeijingChina
  4. 4.School of Mathematical SciencesBeijing Normal UniversityBeijingChina

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