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Therapeutic applications of bone marrow-derived stem cells in liver transplantation for end-stage liver diseases

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  • Cell Biology
  • Published:
Chinese Science Bulletin

Abstract

Today, liver transplantation (LT) is the only established treatment for end-stage liver diseases. The development of LT, including OLT, cadaveric LT, split LT, living donor LT (LDLT), brings hopes to patients with these diseases. However, increasing donor shortage, rejection and life-long immunosuppression with its side effects are the major limitations of this therapy strategy. Bone marrow-derived stem cells (BMDSCs) are capable of differentiating into hepatocyte-like cells and contribute to liver injury repair. The microenvironment of liver injury caused by rejection, ischemia/reperfusion, loss of liver mass, recurrence of HCV and “small-for-size syndrome” after LT can attract a variety of bone marrow-derived stem cell population to the peripheral circulation and then migration to the injury liver to promote the hepatic function restoration. Additionally, BMDSCs can also take part in the functional regeneration of living donor liver after LDLT. This participation in liver regeneration may be associated to the interaction between SDF-1and its receptor CXCR4, involving HGF, IL-8, MMP9, and VEGF/VEGFR-2. BMDSC with its bio-characteristics could maintain the allograft tolerance from different angles and in different ways. In conclusion, BMDSCs transplantation, as a new assistant therapeutic method for LT, will expand the space of LT, and provide more survival opportunities for the patients suffering liver diseases in the future

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Authors and Affiliations

  1. Department of Stem Cell and Regenerative Medicine, Beijing Institute of Transfusion Medicine, Beijing, 100850, China

    Luo HaiYing, Wang YunFang & Pei XueTao

  2. College of Life Science, Jilin University, Changchun, 130062, China

    Luo HaiYing & Kong Wei

Authors
  1. Luo HaiYing
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  2. Wang YunFang
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  3. Kong Wei
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  4. Pei XueTao
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Corresponding author

Correspondence to Pei XueTao.

Additional information

Supported by State 863 High Technology R&D Project of China (Grant No. 2006AA02A107) and National Natural Science Foundation of China (Grant No. 30400415)

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Luo, H., Wang, Y., Kong, W. et al. Therapeutic applications of bone marrow-derived stem cells in liver transplantation for end-stage liver diseases. CHINESE SCI BULL 52, 2449–2456 (2007). https://doi.org/10.1007/s11434-007-0392-9

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  • DOI: https://doi.org/10.1007/s11434-007-0392-9

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