Science China Technological Sciences

, Volume 58, Issue 2, pp 346–351 | Cite as

A novel linear microprobe array for the fabrication of neural microelectrodes

  • ShanShan Zhao
  • WeiHua Pei
  • Hui Zhao
  • YiJun Wang
  • SanYuan Chen
  • YuanFang Chen
  • He Zhang
  • DongMei Guo
  • Qiang Gui
  • HongDa Chen
Article

Abstract

A novel linear microprobe array (LMPA) has been developed by a conventional microfabrication method from silicon. The LMPA leverages the properties of conventional microwire with additional features of naturally formed regular spacing. With the help of periodic microprobe arrays and double-side V-grooves fabricated in advance between each pair of the two microprobes’ rear ends, the number of microprobe units for assembly in one array can be flexibly chosen by cleavage fracture from the LMPA. The fabrication method was demonstrated and the prototype device was assessed by electrochemical impedance spectroscopy (EIS) and in vivo test. The SNR of the spikes recorded was 6.

Keywords

LMPA regular spacing cleavage fracture V-groove 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Yamamoto T. Easy construction of an improved fine wire electrode for chronic single neuron recording in freely moving animals. Physiol Behav, 1987, 39: 649–652CrossRefGoogle Scholar
  2. 2.
    Chorover S L, Deluca A M. A sweet new multiple electrode for chronic single unit recording in moving animals. Physiol Behav, 1972, 9: 671–674CrossRefGoogle Scholar
  3. 3.
    Nicolelis M, Chapin J K. Spatiotemporal structure of somatosensory responses of many-neuron ensembles in the rat ventral posterior medial nucleus of the thalamus. J Neurosci, 1994, 14: 3511–3532Google Scholar
  4. 4.
    Nicolelis M A, Dimitrov D, Carmena J M, et al. Chronic, multisite, multielectrode recordings in macaque monkeys. In: Proceedings of the National Academy of Sciences, 2003, 100: 11041–11046CrossRefGoogle Scholar
  5. 5.
    Fontani G. A technique for long term recording from single neurons in unrestrained behaving animals. Physiol Behav, 1981, 26: 331–333CrossRefGoogle Scholar
  6. 6.
    Strumwasser F. Long-term recording from single neurons in brain of unrestrained mammals. Science, 1958, 127: 469–470CrossRefGoogle Scholar
  7. 7.
    Markwardt N T, Stokol J, Ii R L R. Sub-meninges implantation reduces immune response to neural implants. J Neurosci Meth, 2013, 214: 119–125CrossRefGoogle Scholar
  8. 8.
    Wei W J, Song Y L, Shi W T, et al. A novel microelectrode array probe integrated with electrophysiology reference electrode for neural recording. Key Eng Mater, 2013, 562: 67–73CrossRefGoogle Scholar
  9. 9.
    Zhang X, Zhang R L, Zhang Z G, et al. Measurement of neuronal activity of individual neurons after stroke in the rat using a microwire electrode array. J Neurosci Meth, 2007, 162: 91–100CrossRefGoogle Scholar
  10. 10.
    Winslow B D, Tresco P A. Quantitative analysis of the tissue response to chronically implanted microwire electrodes in rat cortex. Biomaterials, 2010, 31: 1558–1567CrossRefGoogle Scholar
  11. 11.
    Feng H J, Faingold C L. Repeated generalized audiogenic seizures induce plastic changes on acoustically evoked neuronal firing in the amygdala. Brain Res, 2002, 932: 61–69CrossRefGoogle Scholar
  12. 12.
    Verloop A, Holsheimer J. A simple method for the construction of electrode arrays. J Neurosci Meth, 1984, 11: 173–178CrossRefGoogle Scholar
  13. 13.
    Szabo I, Czurko A, Csicsvari J, et al. The application of printed circuit board technology for fabrication of multi-channel micro-drives. J Neurosci Meth, 2001, 105: 105–110CrossRefGoogle Scholar
  14. 14.
    Sato T, Suzuki T, Mabuchi K. A new multi-electrode array design for chronic neural recording, with independent and automatic hydraulic positioning. J Neurosci Meth, 2007, 160: 45–51CrossRefGoogle Scholar
  15. 15.
    Takahashi H, Suzurikawa J, Nakao M, et al. Easy-to-prepare assembly array of tungsten microelectrodes. IEEE T Bio-Med Eng, 2005, 52: 952–956CrossRefGoogle Scholar
  16. 16.
    Liao Y F, Tsai M L, Yen C T, et al. A simple method for fabricating microwire tetrode with sufficient rigidity and integrity without a heat-fusing process. J Neurosci Meth, 2011, 195: 211–215CrossRefGoogle Scholar
  17. 17.
    Cui Z. Micro-Nanofabrication: Technologies and Applications. Beijing: Higher Education Press, 2005. 196–197Google Scholar
  18. 18.
    Campbell P K, Jones K E, Huber R J, et al. A silicon-based, three-dimensional neural interface: Manufacturing processes for an intracortical electrode array. IEEE T Bio-Med Eng, 1991, 38: 758–768CrossRefGoogle Scholar
  19. 19.
    HajjHassan M, Chodavarapu V, Musallam S. Neuro MEMS: Neural probe microtechnologies. Sensors, 2008, 8: 6704–6726CrossRefGoogle Scholar
  20. 20.
    Chen S, Pei W, Gui Q, et al. PEDOT/MWCNT composite film coated microelectrode arrays for neural interface improvement. Sensor Actuat A-Phys, 2013, 193: 141–168CrossRefGoogle Scholar

Copyright information

© Science China Press and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • ShanShan Zhao
    • 1
  • WeiHua Pei
    • 1
  • Hui Zhao
    • 1
  • YiJun Wang
    • 2
  • SanYuan Chen
    • 1
  • YuanFang Chen
    • 1
  • He Zhang
    • 1
  • DongMei Guo
    • 1
  • Qiang Gui
    • 1
  • HongDa Chen
    • 1
  1. 1.State Key Laboratory on Integrated Optoelectronics, Institute of SemiconductorsChinese Academy of SciencesBeijingChina
  2. 2.Institute for Neural ComputationUniversity of California San DiegoSan DiegoUSA

Personalised recommendations