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Science China Life Sciences

, Volume 62, Issue 11, pp 1459–1471 | Cite as

Dynamic modifications of biomacromolecules: mechanism and chemical interventions

  • Chu Wang
  • Peng Zou
  • Caiguang Yang
  • Lei Liu
  • Liang Cheng
  • Xiaopeng He
  • Liang Zhang
  • Yan Zhang
  • Hualiang JiangEmail author
  • Peng R. ChenEmail author
Review

Abstract

Biological macromolecules (proteins, nucleic acids, polysaccharides, etc.) are the building blocks of life, which constantly undergo chemical modifications that are often reversible and spatial-temporally regulated. These dynamic properties of chemical modifications play fundamental roles in physiological processes as well as pathological changes of living systems. The Major Research Project (MRP) funded by the National Natural Science Foundation of China (NSFC)—“Dynamic modifications of biomacromolecules: mechanism and chemical interventions” aims to integrate cross-disciplinary approaches at the interface of chemistry, life sciences, medicine, mathematics, material science and information science with the following goals: (i) developing specific labeling techniques and detection methods for dynamic chemical modifications of biomacromolecules, (ii) analyzing the molecular mechanisms and functional relationships of dynamic chemical modifications of biomacromolecules, and (iii) exploring biomacromolecules and small molecule probes as potential drug targets and lead compounds.

Keywords

chemical biology biomacromolecule dynamic modification modification analysis chemical intervention 

Notes

Supplementary material

11427_2019_9823_MOESM1_ESM.docx (35 kb)
Supplementary material, approximately 35.1 KB.

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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Chu Wang
    • 1
  • Peng Zou
    • 1
  • Caiguang Yang
    • 2
  • Lei Liu
    • 3
  • Liang Cheng
    • 4
  • Xiaopeng He
    • 5
  • Liang Zhang
    • 6
  • Yan Zhang
    • 7
  • Hualiang Jiang
    • 2
    Email author
  • Peng R. Chen
    • 1
    Email author
  1. 1.College of Chemistry and Molecular EngineeringPeking UniversityBeijingChina
  2. 2.Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina
  3. 3.Department of ChemistryTsinghua UniversityBeijingChina
  4. 4.Institute of ChemistryChinese Academy of SciencesBeijingChina
  5. 5.School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghaiChina
  6. 6.Department of Pharmacology and Chemical BiologyShanghai Jiao Tong University School of MedicineShanghaiChina
  7. 7.National Natural Science Foundation of ChinaBeijingChina

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