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Chinese society of cardiology expert consensus statement on the diagnosis and treatment of adult fulminant myocarditis

  • Daowen Wang
  • Jiangang Jiang
  • Sheng Li
  • Yihan Chen
  • Rutai Hui
  • Yan Wang
  • Hong Wang
  • Houjuan Zuo
  • Weijian Hang
  • Ning Zhou
  • Yaling Han
  • Jing Zhang
  • Yundai Chen
  • Jingmin Zhou
  • Junbo Ge
  • Jianan Wang
  • Dingli Xu
  • Bo Yu
  • Yuejin Yang
  • Jun Pu
  • Yong Huo
  • Yugang Dong
  • Dingcheng Xiang
  • Lemin Wang
  • Weiyi Fang
  • Tianlun Yang
  • Chunxia Zhao
  • Song Zhang
  • Xiao Ran
  • Zonggui Wu
  • Chinese Societyof Cardiology
Open Access
Review
  • 297 Downloads

Abstract

Fulminant myocarditis is primarily caused by infection with any number of a variety of viruses. It arises quickly, progresses rapidly, and may lead to severe heart failure or circulatory failure presenting as rapid-onset hypotension and cardiogenic shock, with mortality rates as high as 50%–70%. Most importantly, there are no treatment options, guidelines or an expert consensus statement. Here, we provide the first expert consensus, the Chinese Society of Cardiology Expert Consensus Statement on the Diagnosis and Treatment of Fulminant Myocarditis, based on data from our recent clinical trial (NCT03268642). In this statement, we describe the clinical features and diagnostic criteria of fulminant myocarditis, and importantly, for the first time, we describe a new treatment regimen termed life support-based comprehensive treatment regimen. The core content of this treatment regimen includes (i) mechanical life support (applications of mechanical respirators and circulatory support systems, including intraaortic balloon pump (IABP) and extracorporeal membrane oxygenation (ECMO)), (ii) immunological modulation by using sufficient doses of glucocorticoid, immunoglobulin and (iii) antiviral reagents using neuraminidase inhibitor. The proper application of this treatment regimen may and has helped to save the lives of many patients with fulminant myocarditis.

Keywords

adult fulminant myocarditis diagnosis and treatment expert consensus life support-based comprehensive treatment regimen cardiogenic shock mechanical circulatory support 

Notes

Acknowledgements

All the physicians and nurses of the Departments of Cardiology and some of the physicians and nurses of the Departments of Nephrology at Tongji Hospital, Fuwai Hospital in Beijing, and Zhongshan Hospital of Fudan University in Shanghai contributed to the treatment of fulminant myocarditis patients and the formulation of this consensus. This work was supported in part by the National Key Basic Research Project (2012CB518004), the Precision Medicine Program of China (SQ2017YFSF090157) and the Natural Science Fund Key Projects (81630010).

References

  1. Abdel-Aty, H., Boyé, P., Zagrosek, A., Wassmuth, R., Kumar, A., Messroghli, D., Bock, P., Dietz, R., Friedrich, M.G., and Schulz-Menger, J. (2005). Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis. J Am Coll Cardiol 45, 1815–1822.CrossRefGoogle Scholar
  2. Al-Khatib, S.M., Stevenson, W.G., Ackerman, M.J., Bryant, W.J., Callans, D.J., Curtis, A.B., Deal, B.J., Dickfeld, T., Field, M.E., Fonarow, G.C., et al. (2018). 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: executive summary. Circulation 138.Google Scholar
  3. Ammirati, E., Cipriani, M., Lilliu, M., Sormani, P., Varrenti, M., Raineri, C., Petrella, D., Garascia, A., Pedrotti, P., Roghi, A., et al. (2017a). Survival and left ventricular function changes in fulminant versus nonfulminant acute myocarditis. Circulation 136, 529–545.CrossRefGoogle Scholar
  4. Ammirati, E., Moroni, F., Sormani, P., Peritore, A., Milazzo, A., Quattrocchi, G., Cipriani, M., Oliva, F., Giannattasio, C., Frigerio, M., et al. (2017b). Quantitative changes in late gadolinium enhancement at cardiac magnetic resonance in the early phase of acute myocarditis. Int J Cardiol 231, 216–221.CrossRefGoogle Scholar
  5. Asaumi, Y., Yasuda, S., Morii, I., Kakuchi, H., Otsuka, Y., Kawamura, A., Sasako, Y., Nakatani, T., Nonogi, H., and Miyazaki, S. (2005). Favourable clinical outcome in patients with cardiogenic shock due to fulminant myocarditis supported by percutaneous extracorporeal membrane oxygenation. Eur Heart J 26, 2185–2192.CrossRefGoogle Scholar
  6. Baccouche, H., Mahrholdt, H., Meinhardt, G., Merher, R., Voehringer, M., Hill, S., Klingel, K., Kandolf, R., Sechtem, U., and Yilmaz, A. (2009). Diagnostic synergy of non-invasive cardiovascular magnetic resonance and invasive endomyocardial biopsy in troponin-positive patients without coronary artery disease. Eur Heart J 30, 2869–2879.CrossRefGoogle Scholar
  7. Badawy, S.S.I., and Fahmy, A. (2012). Efficacy and cardiovascular tolerability of continuous veno-venous hemodiafiltration in acute decompensated heart failure: a randomized comparative study. J Crit Care 27, 106.e7–106.e13.CrossRefGoogle Scholar
  8. Barrie, M., McKnight, L., and Solanki, P. (2012). Rapid resolution of acute fulminant myocarditis after IVIG and steroid treatment. Case Rep Crit Care 2012, 1–4.CrossRefGoogle Scholar
  9. Bjelakovic, B., Vukomanovic, V., and Jovic, M. (2016). Fulminant myocarditis in children successfully treated with high dose of methyl-prednisolone. Ind J Pediatr 83, 268–269.CrossRefGoogle Scholar
  10. Bock, C.T., Klingel, K., and Kandolf, R. (2010). Human parvovirus B19-associated myocarditis. New Engl J Med 362, 1248–1249.CrossRefGoogle Scholar
  11. Bulut, D., Scheeler, M., Wichmann, T., Börgel, J., Miebach, T., and Mügge, A. (2010). Effect of protein A immunoadsorption on T cell activation in patients with inflammatory dilated cardiomyopathy. Clin Res Cardiol 99, 633–638.CrossRefGoogle Scholar
  12. Burns, D.J.P., and Quantz, M.A. (2015). Use of the Impella 5.0 device as a bridge to recovery in adult fulminant viral myocarditis. Innov-Tech Techniques Cardiothor Vascular Surg 10, 279–281.CrossRefGoogle Scholar
  13. Caforio, A.L.P., Pankuweit, S., Arbustini, E., Basso, C., Gimeno-Blanes, J., Felix, S.B., Fu, M., Heliö, T., Heymans, S., Jahns, R., et al. (2013). Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European society of cardiology working group on myocardial and pericardial diseases. Eur Heart J 34, 2636–2648.CrossRefGoogle Scholar
  14. Caforio, A.L.P., Malipiero, G., Marcolongo, R., and Iliceto, S. (2017). Myocarditis: a clinical overview. Curr Cardiol Rep 19, 63.CrossRefGoogle Scholar
  15. Chakko, S., Woska, D., Martinez, H., Marchena, E.D., Futterman, L., Kessler, K.M., and Myerburg, R.J. (1991). Clinical, radiographic, and hemodynamic correlations in chronic congestive heart failure: conflicting results may lead to inappropriate care. Am J Med 90, 353–359.CrossRefGoogle Scholar
  16. Chen, H.S., Wang, W., Wu, S.N., and Liu, J.P. (2013). Corticosteroids for viral myocarditis. Cochrane Database Syst Rev 20.Google Scholar
  17. Chen, J., Lai, J., Yang, L., Ruan, G., Chaugai, S., Ning, Q., Chen, C., and Wang, D.W. (2016). Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1. Brit J Pharmacol 173, 545–561.CrossRefGoogle Scholar
  18. Cheng, R., Hachamovitch, R., Kittleson, M., Patel, J., Arabia, F., Moriguchi, J., Esmailian, F., and Azarbal, B. (2014). Clinical outcomes in fulminant myocarditis requiring extracorporeal membrane oxygenation: a weighted meta-analysis of 170 patients. J Card Fail 20, 400–406.CrossRefGoogle Scholar
  19. Deubner, N., Berliner, D., Schlipp, A., Gelbrich, G., Caforio, A.L.P., Felix, S.B., Fu, M., Katus, H., Angermann, C.E., Lohse, M.J., et al. (2010). Cardiac β1-adrenoceptor autoantibodies in human heart disease: rationale and design of the Etiology, Titre-C ourse, and Survival (ETiCS) Study. Eur J Heart Fail 12, 753–762.CrossRefGoogle Scholar
  20. Diddle, J.W., Almodovar, M.C., Rajagopal, S.K., Rycus, P.T., and Thiagarajan, R.R. (2015). Extracorporeal membrane oxygenation for the support of adults with acute myocarditis. Crit Care Med 43, 1016–1025.CrossRefGoogle Scholar
  21. Drucker, N.A., Colan, S.D., Lewis, A.B., Beiser, A.S., Wessel, D.L., Takahashi, M., Baker, A.L., Perez-Atayde, A.R., and Newburger, J.W. (1994). Gamma-globulin treatment of acute myocarditis in the pediatric population. Circulation 89, 252–257.CrossRefGoogle Scholar
  22. Felix, S.B., Beug, D., and Dörr, M. (2015). Immunoadsorption therapy in dilated cardiomyopathy. Expert Rev Cardiovasc Ther 13, 145–152.CrossRefGoogle Scholar
  23. Felker, G.M., Boehmer, J.P., Hruban, R.H., Hutchins, G.M., Kasper, E.K., Baughman, K.L., and Hare, J.M. (2000). Echocardiographic findings in fulminant and acute myocarditis. J Am Coll Cardiol 36, 227–232.CrossRefGoogle Scholar
  24. Felker, G.M., Mentz, R.J., Teerlink, J.R., Voors, A.A., Pang, P.S., Ponikowski, P., Greenberg, B.H., Filippatos, G., Davison, B.A., Cotter, G., et al. (2015). Serial high sensitivity cardiac troponin T measurement in acute heart failure: insights from the RELAX-AHF study. Eur J Heart Fail 17, 1262–1270.CrossRefGoogle Scholar
  25. Fung, G., Luo, H., Qiu, Y., Yang, D., and McManus, B. (2016). Myocarditis. Circ Res 118, 496–514.CrossRefGoogle Scholar
  26. Ganatra, S., and Neilan, T.G. (2018). Immune checkpoint inhibitorassociated myocarditis. Oncologist 23, 879–886.CrossRefGoogle Scholar
  27. Ginsberg, F., and Parrillo, J.E. (2013). Fulminant myocarditis. Crit Care Clin 29, 465–483.CrossRefGoogle Scholar
  28. Goland, S., Czer, L.S.C., Siegel, R.J., Tabak, S., Jordan, S., Luthringer, D., Mirocha, J., Coleman, B., Kass, R.M., and Trento, A. (2008). Intravenous immunoglobulin treatment for acute fulminant inflammatory cardiomyopathy: series of six patients and review of literature. Can J Cardiol 24, 571–574.CrossRefGoogle Scholar
  29. JCS Joint Working Group, (2011). Guidelines for diagnosis and treatment of myocarditis (JCS 2009). Circ J 75, 734–743.CrossRefGoogle Scholar
  30. Gupta, S., Markham, D.W., Drazner, M.H., and Mammen, P.P. (2008). Fulminant myocarditis. Nat Rev Cardiol 5, 693–706.CrossRefGoogle Scholar
  31. Hsu, K.H., Chi, N.H., Yu, H.Y., Wang, C.H., Huang, S.C., Wang, S.S., Ko, W.J., and Chen, Y.S. (2011) Extracorporeal membranous oxygenation support for acute fulminant myocarditis: analysis of a single center's experience. Eur J Cardiothoracic Surg.Google Scholar
  32. Hu, W.H., Liu, C.W., Hu. W., Lu, J., Zhu, Y., Wang, J.R., and Liu, B.W. (2014). Analysis of ECMO treatment in five fulminant myocarditis patients. Chin J Crit Care Med 7, 354–357.Google Scholar
  33. Hufnagel, G., Pankuweit, S., Richter, A., Schonian, U., and Maisch, B. (1995). The European study of epidemiology and treatment of cardiac inflammatory disease (ESETCID). Eur Heart J 16, 173–175.CrossRefGoogle Scholar
  34. Ihdayhid, A.R., Chopra, S., and Rankin, J. (2014). Intra-aortic balloon pump. Curr Opin Cardiol 29, 285–292.CrossRefGoogle Scholar
  35. Isogai, T., Yasunaga, H., Matsui, H., Tanaka, H., Horiguchi, H., and Fushimi, K. (2015). Effect of intravenous immunoglobulin for fulminant myocarditis on in-hospital mortality: propensity score analyses. J Card Fail 21, 391–397.CrossRefGoogle Scholar
  36. Jensen, L.D., and Marchant, D.J. (2016). Emerging pharmacologic targets and treatments for myocarditis. Pharmacol Ther 161, 40–51.CrossRefGoogle Scholar
  37. Jiang, L., Miao, K., Cui, G.N., Zuo, H.J., Li, R., Wang, D.W., and Jiang, J. G. (2017). Efficacy of circulatory support in patients with cardiogenic shock. J Intern Inten Med (China) 23, 459–461.Google Scholar
  38. Johnson, D.B., Balko, J.M., Compton, M.L., Chalkias, S., Gorham, J., Xu, Y., Hicks, M., Puzanov, I., Alexander, M.R., Bloomer, T.L., et al. (2016). Fulminant myocarditis with combination immune checkpoint blockade. New Engl J Med 375, 1749–1755.CrossRefGoogle Scholar
  39. Kindermann, I., Barth, C., Mahfoud, F., Ukena, C., Lenski, M., Yilmaz, A., Klingel, K., Kandolf, R., Sechtem, U., Cooper, L.T., et al. (2012). Update on myocarditis. J Am Coll Cardiol 59, 779–792.CrossRefGoogle Scholar
  40. Kishimoto, C., Shioji, K., Hashimoto, T., Nonogi, H., Lee, J.D., Kato, S., Hiramitsu, S., and Morimoto, S. (2014). Therapy with immunoglobulin in patients with acute myocarditis and cardiomyopathy: analysis of leukocyte balance. Heart Vessels 29, 336–342.CrossRefGoogle Scholar
  41. Kühl, U., Lassner, D., von Schlippenbach, J., Poller, W., and Schultheiss, H.P. (2012). Interferon-Beta improves survival in enterovirus-associated cardiomyopathy. J Am Coll Cardiol 60, 1295–1296.CrossRefGoogle Scholar
  42. Lazaros, G., Oikonomou, E., and Tousoulis, D. (2017). Established and novel treatment options in acute myocarditis, with or without heart failure. Expert Rev Cardiovasc Ther 15, 25–34.CrossRefGoogle Scholar
  43. Leone, O., Veinot, J.P., Angelini, A., Baandrup, U.T., Basso, C., Berry, G., Bruneval, P., Burke, M., Butany, J., Calabrese, F., et al. (2012). 2011 consensus statement on endomyocardial biopsy from the association for European cardiovascular pathology and the society for cardiovascular pathology. Cardiovasc Pathol 21, 245–274.CrossRefGoogle Scholar
  44. Li, S., Ran, X., Cui, G., Miao, K., Zhao, C., Yuan, S., Yan, J., Lan, L., Liu, Z., Zhou, N., et al. (2017). A life support based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis—a multiple center study. New Engl J Med, Submitted.Google Scholar
  45. Lorusso, R., Centofanti, P., Gelsomino, S., Barili, F., Di Mauro, M., Orlando, P., Botta, L., Milazzo, F., Actis Dato, G., Casabona, R., et al. (2016). Venoarterial extracorporeal membrane oxygenation for acute fulminant myocarditis in adult patients: a 5-year multi-institutional experience. Ann Thorac Surg 101, 919–926.CrossRefGoogle Scholar
  46. Luyt, C.E., Hékimian, G., and Ginsberg, F. (2016). What’s new in myocarditis? Intens Care Med 42, 1055–1057.CrossRefGoogle Scholar
  47. Luyt, C.E., Landivier, A., Leprince, P., Bernard, M., Pavie, A., Chastre, J., and Combes, A. (2012). Usefulness of cardiac biomarkers to predict cardiac recovery in patients on extracorporeal membrane oxygenation support for refractory cardiogenic shock. J Crit Care 27, 524.e7–524. e14.CrossRefGoogle Scholar
  48. Maejima, Y., Yasu, T., Kubo, N., Kawahito, K., Omura, N., Katsuki, T., Tsukamoto, Y., Sugawara, Y., Hashimoto, S., Tsuruya, Y., et al. (2004). Long-term prognosis of fulminant myocarditis rescued by percutaneous cardiopulmonary support device. Circ J 68, 829–833.CrossRefGoogle Scholar
  49. Mahfoud, F., Gärtner, B., Kindermann, M., Ukena, C., Gadomski, K., Klingel, K., Kandolf, R., Böhm, M., and Kindermann, I. (2011). Virus serology in patients with suspected myocarditis: utility or futility? Eur Heart J 32, 897–903.CrossRefGoogle Scholar
  50. Maisch, B., Ruppert, V., and Pankuweit, S. (2014). Management of fulminant myocarditis: a diagnosis in search of its etiology but with therapeutic options. Curr Heart Fail Rep 11, 166–177.CrossRefGoogle Scholar
  51. Maisel, A., Mueller, C., Nowak, R., Peacock, W.F., Landsberg, J.W., Ponikowski, P., Mockel, M., Hogan, C., Wu, A.H.B., Richards, M., et al. (2010). Mid-region pro-hormone markers for diagnosis and prognosis in acute dyspnea. J Am Coll Cardiol 55, 2062–2076.CrossRefGoogle Scholar
  52. Maisel, A.S., Krishnaswamy, P., Nowak, R.M., McCord, J., Hollander, J.E., Duc, P., Omland, T., Storrow, A.B., Abraham, W.T., Wu, A.H.B., et al. (2002). Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. New Engl J Med 347, 161–167.CrossRefGoogle Scholar
  53. Mariani, J., Macchia, A., Belziti, C., Deabreu, M., Gagliardi, J., Doval, H., Tognoni, G., and Tajer, C. (2011). Noninvasive ventilation in acute cardiogenic pulmonary edema: a meta-analysis of randomized controlled trials. J Card Fail 17, 850–859.CrossRefGoogle Scholar
  54. McCarthy, R.E., Boehmer, J.P., Hruban, R.H., Hutchins, G.M., Kasper, E. K., Hare, J.M., and Baughman, K.L. (2000). Long-term outcome of fulminant myocarditis as compared with acute (nonfulminant) myocarditis. New Engl J Med 342, 690–695.CrossRefGoogle Scholar
  55. McMurray, J.J.V., Adamopoulos, S., Anker, S.D., Auricchio, A., Böhm, M., Dickstein, K., Falk, V., Filippatos, G., Fonseca, C., Gomez-Sanchez, M. A., et al. (2012). ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012. Eur J Heart Fail 14, 803–869.CrossRefGoogle Scholar
  56. Miao, K., Chen, C., Cui, G.N., Ma, F., Wang, H., Wang, D.W., Jiang, J.G. (2017). Statistical analysis on differences in different treatments for adults with fulminant myocarditis. J Intern IntenMed (China) 23, 465–468.Google Scholar
  57. Moe, G.W., Howlett, J., Januzzi, J.L., Zowall, H., and Zowall, H. (2007). N-terminal pro-B-type natriuretic peptide testing improves the management of patients with suspected acute heart failure: primary results of the Canadian prospective randomized multicenter IMPROVECHF study. Circulation 115, 3103–3110.CrossRefGoogle Scholar
  58. Mueller, C., Laule-Kilian, K., Scholer, A., Frana, B., Rodriguez, D., Schindler, C., Marsch, S., and Perruchoud, A.P. (2004). Use of B-type natriuretic peptide for the management of women with dyspnea. Am J Cardiol 94, 1510–1514.CrossRefGoogle Scholar
  59. Nakamura, T., Ishida, K., Taniguchi, Y., Nakagawa, T., Seguchi, M., Wada, H., Sugawara, Y., Funayama, H., Mitsuhashi, T., and Momomura, S.I. (2015). Prognosis of patients with fulminant myocarditis managed by peripheral venoarterial extracorporeal membranous oxygenation support: a retrospective single-center study. J Intens Care 3, 5.CrossRefGoogle Scholar
  60. Nakashima, H., Umeyama, Y., and Minami, K. (2013). Successive immunosuppressive treatment of fulminant myocarditis that is refractory to mechanical circulatory support. Am J Case Rep 14, 116–119.CrossRefGoogle Scholar
  61. Nikolaou, M., Parissis, J., Yilmaz, M.B., Seronde, M.F., Kivikko, M., Laribi, S., Paugam-Burtz, C., Cai, D., Pohjanjousi, P., Laterre, P.F., et al. (2013). Liver function abnormalities, clinical profile, and outcome in acute decompensated heart failure. Eur Heart J 34, 742–749.CrossRefGoogle Scholar
  62. Okai, I., Inoue, K., Maruyama, M., Maruyama, S., Komatsu, K., Nishizawa, H., Okazaki, S., Fujiwara, Y., Sumiyoshi, M., and Daida, H. (2012). Transbrachial intra-aortic balloon pumping for a patient with fulminant myocarditis. Heart Vessels 27, 639–642.CrossRefGoogle Scholar
  63. Page, R.L., Joglar, J.A., Caldwell, M.A., Calkins, H., Conti, J.B., Deal, B. J., Estes Iii, N.A.M., Field, M.E., Goldberger, Z.D., Hammill, S.C., et al. (2016). 2015 ACC/AHA/HRS guideline for the management of adult patients with supraventricular tachycardia: executive summary. J Am Coll Cardiol 67, 1575–1623.CrossRefGoogle Scholar
  64. Parekh, D., Jeewa, A., Tume, S.C., Dreyer, W.J., Pignatelli, R., Horne, D., Justino, H., and Qureshi, A.M. (2018). Percutaneous mechanical circulatory support using Impella devices for decompensated cardiogenic shock. Asaio J 64, 98–104.CrossRefGoogle Scholar
  65. Park, M., Sangean, M.C., Volpe, M.S., Feltrim, M.I.Z., Nozawa, E., Leite, P.F., Passos Amato, M.B., and Lorenzi-Filho, G. (2004). Randomized, prospective trial of oxygen, continuous positive airway pressure, and bilevel positive airway pressure by face mask in acute cardiogenic pulmonary edema. Crit Care Med 32, 2407–2415.CrossRefGoogle Scholar
  66. Pelliccia, F., Kaski, J.C., Crea, F., and Camici, P.G. (2017). Pathophysiology of Takotsubo syndrome. Circulation 135, 2426–2441.CrossRefGoogle Scholar
  67. Pinamonti, B., Alberti, E., Cigalotto, A., Dreas, L., Salvi, A., Silvestri, F., and Camerini, F. (1988). Echocardiographic findings in myocarditis. Am J Cardiol 62, 285–291.CrossRefGoogle Scholar
  68. Pollack, A., Kontorovich, A.R., Fuster, V., and Dec, G.W. (2015). Viral myocarditis-diagnosis, treatment options and current controversies. Nat Rev Cardiol 12, 670–680.CrossRefGoogle Scholar
  69. Ponikowski, P., Voors, A.A., Anker, S.D., Bueno, H., Cleland, J.G.F., Coats, A.J.S., Falk, V., González-Juanatey, J.R., Harjola, V.P., Jankowska, E.A., et al. (2016). 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 37, 2129–2200.CrossRefGoogle Scholar
  70. Pozzi, M., Banfi, C., Grinberg, D., Koffel, C., Bendjelid, K., Robin, J., Giraud, R., and Obadia, J.F. (2016). Veno-arterial extracorporeal membrane oxygenation for cardiogenic shock due to myocarditis in adult patients. J Thorac Dis 8, e495–E502.CrossRefGoogle Scholar
  71. Priori, S.G., Blomström-Lundqvist, C., Mazzanti, A., Blom, N., Borggrefe, M., Camm, J., Elliott, P.M., Fitzsimons, D., Hatala, R., Hindricks, G., et al. (2015). 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Europace euv319.Google Scholar
  72. Rodríguez, A., Alvarez-Rocha, L., Sirvent, J.M., Zaragoza, R., Nieto, M., Arenzana, A., Luque, P., Socías, L., Martín, M., Navarro, D., et al. (2012). Recomendaciones del Grupo de Trabajo Enfermedades Infecciosas (GTEI) de la Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (SEMICYUC) y el Grupo de Estudio de Infecciones en el Paciente Crítico (GEIPC) de la Sociedad Española de Enfermedades Infecciosas y Microbiología clínica (SEIMC) para el diagnóstico y tratamiento de la gripe A/H1N1 en pacientes adultos graves hospitalizados en las Unidades de Cuidados Intensivos. Med Intensiva 36, 103–137.CrossRefGoogle Scholar
  73. Ryu, D.R., Heo, J.W., Lee, S.H., Lee, W., Choi, J.W., Kim, H.Y., Lee, B.K., and Cho, B.R. (2013). Fulminant myocarditis: the role of cardiac magnetic resonance imaging. Int J Cardiol 168, e58–e59.CrossRefGoogle Scholar
  74. Saeed, M., Liu, H., Liang, C.H., and Wilson, M.W. (2017). Magnetic resonance imaging for characterizing myocardial diseases. Int J Cardiovasc Imag 33, 1395–1414.CrossRefGoogle Scholar
  75. Schmidt, M., Burrell, A., Roberts, L., Bailey, M., Sheldrake, J., Rycus, P.T., Hodgson, C., Scheinkestel, C., Cooper, D.J., Thiagarajan, R.R., et al. (2015). Predicting survival after ECMO for refractory cardiogenic shock: the survival after veno-arterial-ECMO (SAVE)-score. Eur Heart J 36, 2246–2256.CrossRefGoogle Scholar
  76. Shioji, K., Kishimoto, C., and Sasayama, S. (2001). Fc receptor-mediated inhibitory effect of immunoglobulin therapy on autoimmune giant cell myocarditis: concomitant suppression of the expression of dendritic cells. Circ Res 89, 540–546.CrossRefGoogle Scholar
  77. Sodhi, N., and Lasala, J.M. (2017). Mechanical circulatory support in acute decompensated heart failure and shock. Interv Cardiol Clin 6, 387–405.Google Scholar
  78. Sun, D., Ding, H., Zhao, C., Li, Y., Wang, J., Yan, J., and Wang, D.W. (2017). Value of SOFA, APACHE IV and SAPS II scoring systems in predicting short-term mortality in patients with acute myocarditis. Oncotarget 8.Google Scholar
  79. Thiele, H., Zeymer, U., Neumann, F.J., Ferenc, M., Olbrich, H.G., Hausleiter, J., de Waha, A., Richardt, G., Hennersdorf, M., Empen, K., et al. (2013). Intra-aortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock (IABPSHOCK II): final 12 month results of a randomised, open-label trial. Lancet 382, 1638–1645.CrossRefGoogle Scholar
  80. Tong, L., and Zhu, Y.F. (2014). Clinical analysis of 36 children with fulminant myocarditis. ChongQin Med 4241–4242.Google Scholar
  81. Ukena, C., Mahfoud, F., Kindermann, I., Kandolf, R., Kindermann, M., and Böhm, M. (2011). Prognostic electrocardiographic parameters in patients with suspected myocarditis. Eur J Heart Fail 13, 398–405.CrossRefGoogle Scholar
  82. Ukimura, A., Izumi, T., Matsumori, A., and Clinical Research Committee on Myoc, A. (2010). A national survey on myocarditis associated with the 2009 influenza A (H1N1) pandemic in Japan. Circ J 74, 2193–2199.CrossRefGoogle Scholar
  83. Ukimura, A., Ooi, Y., Kanzaki, Y., Inomata, T., and Izumi, T. (2013). A national survey on myocarditis associated with influenza H1N1pdm2009 in the pandemic and postpandemic season in Japan. J Infection ChemoTher 19, 426–431.CrossRefGoogle Scholar
  84. Unverzagt, S., Buerke, M., de Waha, A., Haerting, J., Pietzner, D., Seyfarth, M., Thiele, H., Werdan, K., Zeymer, U., and Prondzinsky, R. (2015). Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock. Cochrane Database Syst Rev 75.Google Scholar
  85. van Diepen, S., Katz, J.N., Albert, N.M., Henry, T.D., Jacobs, A.K., Kapur, N.K., Kilic, A., Menon, V., Ohman, E.M., Sweitzer, N.K., et al. (2017). Contemporary management of cardiogenic shock: a scientific statement from the American heart association. Circulation 136, e232.CrossRefGoogle Scholar
  86. Vital, F.M., Ladeira, M.T., and Atallah, A.N. (2013). Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema. Cochrane Database Syst Rev, CD005351.CrossRefGoogle Scholar
  87. von Knobelsdorff-Brenkenhoff, F., Schüler, J., Dogangüzel, S., Dieringer, M.A., Rudolph, A., Greiser, A., Kellman, P., and Schulz-Menger, J. (2017). Detection and monitoring of acute myocarditis applying quantitative cardiovascular magnetic resonance. Circ Cardiovasc Imag 10.Google Scholar
  88. Wang, D.W. (2017). Contemporary management of fulminant myocarditis. J Intern Inten Med (China) 23, 441–442.Google Scholar
  89. Wang, Y., Yuan, Y., Wang, Q., Shao, W., and Cui, L. (2013). Sixty-four cases of fulminant myocarditis in children. Chin J Pr Pediatr 12, 935–937.Google Scholar
  90. Wei, X.X., Wang, D.W., and Li, S. (2017). Application of emergency coronary angiography in adult patients with fulminant myocarditis. J Intern Inten Med (China) 23, 462–464.Google Scholar
  91. Weng, C.L., Zhao, Y.T., Liu, Q.H., Fu, C.J., Sun, F., Ma, Y.L., Chen, Y.W., and He, Q.Y. (2010). Meta-analysis: noninvasive ventilation in acute cardiogenic pulmonary edema. Ann Intern Med 152, 590–600.CrossRefGoogle Scholar
  92. Yang, G.T., Ding, J., Guan, M.Z., Zhang, D.H., Ding, M.Y., Gu, R.X., Sun, Y., Xu, G.Q., Peng, C.F., and Han, Y.L. (2016). Extracorporeal membrane oxygenation for rescuing fulminant myocarditis patients complicated with multiple organ failure. Clin J Med Officers 44, 1140–1143.Google Scholar
  93. Yoshimizu, N., Tominaga, T., Ito, T., Nishida, Y., Wada, Y., Sohmiya, K., Tanaka, S., Shibata, K., Kanzaki, Y., Ukimura, A., et al. (2014). Repetitive fulminant influenza myocarditis requiring the use of circulatory assist devices. Intern Med 53, 109–114.CrossRefGoogle Scholar
  94. Yu, D.Q., Wang, Y., Ma, G.Z., Xu, R.H., Cai, Z.X., Ni, C.M., Chen, P., and Zhu, Z.D. (2014). Intravenous immunoglobulin in the therapy of adult acute fulminant myocarditis: a retrospective study. Exp Ther Med 7, 97–102.CrossRefGoogle Scholar
  95. Zeymer, U., and Thiele, H. (2017). Mechanical support for cardiogenic shock. J Am Coll Cardiol 69, 288–290.CrossRefGoogle Scholar
  96. Zhang, L., Wei, T.T., Li, Y., Li, J., Fan, Y., Huang, F.Q., Cai, Y.Y., Ma, G., Liu, J.F., Chen, Q.Q., et al. (2018). Functional metabolomics characterizes a key role for N-acetylneuraminic acid in coronary artery diseases. Circulation 137, 1374–1390.CrossRefGoogle Scholar
  97. Zhou, N., Zuo, H., Su, Y., Miao, K., Jiang, J., Wang, L., and Wang, W. D. (2017). Clinical characteristics of old patients with fulminant myocarditis. J Crit Care Intern Med 23, 456–458.Google Scholar

Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Daowen Wang
    • 1
  • Jiangang Jiang
    • 1
  • Sheng Li
    • 1
  • Yihan Chen
    • 2
  • Rutai Hui
    • 3
  • Yan Wang
    • 1
  • Hong Wang
    • 1
  • Houjuan Zuo
    • 1
  • Weijian Hang
    • 1
  • Ning Zhou
    • 1
  • Yaling Han
    • 4
  • Jing Zhang
    • 5
  • Yundai Chen
    • 6
    • 7
  • Jingmin Zhou
    • 7
  • Junbo Ge
    • 8
  • Jianan Wang
    • 9
  • Dingli Xu
    • 10
  • Bo Yu
    • 3
  • Yuejin Yang
    • 11
  • Jun Pu
    • 12
  • Yong Huo
    • 13
  • Yugang Dong
    • 14
  • Dingcheng Xiang
    • 15
  • Lemin Wang
    • 16
  • Weiyi Fang
    • 17
  • Tianlun Yang
    • 1
  • Chunxia Zhao
    • 18
  • Song Zhang
    • 1
  • Xiao Ran
    • 19
  • Zonggui Wu
    • 20
  • Chinese Societyof Cardiology
  1. 1.Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science & TechnologyWuhanChina
  2. 2.Department of Cardiology, East HospitalTongji University School of MedicineShanghaiChina
  3. 3.Department of Cardiology, National Center for Cardiovascular Diseases, Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  4. 4.Department of CardiologyGeneral Hospital of Shenyang Military RegionShenyangChina
  5. 5.Coronary Care UnitHuazhong Cardiovascular HospitalZhengzhouChina
  6. 6.Department of CardiologyChinese PLA General HospitalBeijingChina
  7. 7.Shanghai Institute of Cardiovascular Diseases, Zhongshan HospitalFudan UniversityShanghaiChina
  8. 8.Department of Cardiology, The Second Affiliated Hospital, School of MedicineZhejiang UniversityHangzhouChina
  9. 9.Department of Cardiology, Nanfang HospitalSouthern Medical UniversityGuangzhouChina
  10. 10.Department of Cardiology2nd Affiliated Hospital of Harbin Medical UniversityHarbinChina
  11. 11.Department of Cardiology, Renji Hospital, School of MedicineShanghai Jiao Tong UniversityShanghaiChina
  12. 12.Department of CardiologyPeking University First HospitalBeijingChina
  13. 13.Department of Cardiologythe First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina
  14. 14.Department of CardiologyGuangzhou General Hospital of Guangzhou Military CommandGuangzhouChina
  15. 15.Department of Cardiology, Tongji HospitalTongji University School of MedicineShanghaiChina
  16. 16.Department of Cardiology, Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiChina
  17. 17.Department of CardiologyXiangya Hospital of Central South UniversityChangshaChina
  18. 18.Cardiovascular Department, Xin Hua HospitalAffiliated Hospital of Shanghai Jiao Tong UniversityShanghaiChina
  19. 19.Intensive Care Unit, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science & TechnologyWuhanChina
  20. 20.Department of Cardiology, Changzheng HospitalThe Second Military Medical UniversityShanghaiChina

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