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Science China Life Sciences

, Volume 61, Issue 11, pp 1432–1436 | Cite as

Structural and functional insights into MCR-2 mediated colistin resistance

  • Xudong Wang
  • Qiong Lu
  • Jianxun Qi
  • Yan Chai
  • Youchun Wang
  • George Fu GaoEmail author
Letter to the Editor

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Notes

Acknowledgements

We are grateful to Dr Gary Wong, Hao Song, Shuguang Tan and Lifeng Fu for helping prepare the figures and revise the manuscript. This work was supported by the Chinese Academy of Sciences (CAS) Strategic Priority Research Program (XDB08020100), the External Cooperation Program of Chinese Academy of Sciences (153211KYSB20160001) and the National Key Plan for Scientific Research and Development of China (2016YFD0500305). George Fu Gao is a leading principal investigator of the National Natural Science Foundation of China (NSFC) Innovative Research Group (81621091). The atomic coordinates and structure factors have been deposited in the Protein Data Bank with PDB ID code 6A7W. X-ray data were collected at beam line 17U of the Shanghai Synchrotron Radiation Facility (SSRF).

Supplementary material

11427_2018_9363_MOESM1_ESM.doc (95 kb)
Table S1. NanoLC-MS/MS analysis of purified full-length MCR-2 protein in DDM detergent
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Table S2. Data collection and refinement statistics
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Table S3. The information and accession numbers of the MCR-2 homolog proteins used for alignment and conserved analysis, related to Figure 2.
11427_2018_9363_MOESM4_ESM.docx (27 kb)
Supplementary Materials
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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Xudong Wang
    • 1
    • 2
  • Qiong Lu
    • 1
    • 3
  • Jianxun Qi
    • 1
  • Yan Chai
    • 1
  • Youchun Wang
    • 3
  • George Fu Gao
    • 1
    • 2
    • 4
    • 5
    Email author
  1. 1.CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of MicrobiologyChinese Academy of SciencesBeijingChina
  2. 2.College of Life SciencesUniversity of Chinese Academy of SciencesBeijingChina
  3. 3.Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, Division of HIV/AIDS and Sexually Transmitted Virus VaccinesNational Institutes for Food and Drug ControlBeijingChina
  4. 4.National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention (China CDC)BeijingChina
  5. 5.Research Network of Immunity and Health (RNIH), Beijing Institutes of Life ScienceChinese Academy of SciencesBeijingChina

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