A combination of follicle stimulating hormone, estradiol and age is associated with the pregnancy outcome for women undergoing assisted reproduction: a retrospective cohort analysis
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To investigate the effect of basal hormone levels including follicle stimulating hormone (FSH) and estradiol (E2) and age on the pregnancy outcomes in women undergoing in vitro fertilization and embryo transfer (IVF-ET), we designed a retrospective cohort analysis and collected information of patients undergoing IVF between January 2014 and April 2017. We found that young women had much better pregnancy outcomes than older women regardless of the hormone levels. The pregnancy outcomes declined in young women with high basal E2, even though they had normal FSH. Older women with higher FSH had a worse outcome of pregnancy, especially with increased E2 level. The results suggest that a combination of FSH, E2 and age could effectively predict the pregnancy outcome for women undergoing IVF-ET, and we should encourage infertile women with diminished ovarian reserve, especially young infertile women, to try the assisted reproduction as early as possible. After 40-yearold, the cost-benefit ratio should be considered according to the ovarian function.
Keywordsfollicle stimulating hormone estradiol age pregnancy outcome assisted reproduction
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We are very grateful to the support of the International Peace Maternity and Child Health Hospital for the project. Thanks to all clinic staff who helped to access to medical records. This work was supported by the Special Fund for the National Key Research and Development Plan Grant (2017YFC1001300 to Hefeng Huang and Guolian Ding), the Major Program of National Natural Science Foundation of China (81490742 to Hefeng Huang), the National Natural Science Foundation of China (31571556 to Guolian Ding), and the Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai (2017YQ047 to Guolian Ding).
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