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Association between serum somatostatin levels and glucose-lipid metabolism in the Jino ethnic minority and Han Chinese population

  • Shiyun Wang
  • Rong Zhang
  • Xuhong Hou
  • Fusong Jiang
  • Jie Wang
  • Zhen He
  • Feng Jiang
  • Cheng Hu
  • Weiping Jia
Research Paper
  • 3 Downloads

Abstract

We aim to investigate the relationship between serum somatostatin (SST) levels and glucose-lipid metabolism at various stages of glucose tolerance in the Jino ethnic minority (n=111) and Han population (n=113) of Yunnan Province, southwest China. Anthropometric parameters and biochemical traits were measured. Serum SST and plasma glucagon levels were tested. Participants were divided into three subgroups: isolated fasting hyperglycemia (IFH), isolated post challenge hyperglycemia (IPH) and normal glucose tolerance (NGT). SST levels were found lower while glucagon levels were significantly higher in the Jino ethnic with IPH (P=0.0026 and P=0.0069, respectively). Fasting glucose and high density lipoprotein-cholesterol (HDL-C) levels were higher (P=0.0055 and P=0.0021, respectively) and fasting insulin levels and homeostasis model assessments β-cell function were lower (P=0.0479 and P=0.0007, respectively) in the Jino population. After adjusting for confounding factors, the serum SST level was associated with glucagon (P<0.0001) in both populations. The SST level was correlated with fasting Cpeptide (P=0.0267) in Jino and HDL-C levels in Han (P=0.0079). Our findings suggest that serum SST levels and plasma glucagon levels may vary in subjects with IPH between two ethnics.

Keywords

somatostatin glucagon hyperglycemia Jino ethnic Han Chinese 

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Notes

Acknowledgements

We want to acknowledge Radioimmunology and Clinical Laboratory (Luwan Branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine) for providing technical support. This work was supported by the National Natural Science Foundation of China (91331110), the Innovation Fund for PhD Students from Shanghai Jiao Tong University School of Medicine (BXJ201738), the Innovation Foundation of Translational Medicine of Shanghai Jiao Tong University School of Medicine (15ZH4006) and Shanghai SJTUSM Biobank. We thank all the research subjects for their participation and the skillful work of all the medical staff at the Shanghai Clinical Center for Diabetes.

Supplementary material

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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Shiyun Wang
    • 1
  • Rong Zhang
    • 1
  • Xuhong Hou
    • 1
  • Fusong Jiang
    • 1
  • Jie Wang
    • 1
  • Zhen He
    • 1
  • Feng Jiang
    • 1
  • Cheng Hu
    • 1
    • 2
  • Weiping Jia
    • 1
  1. 1.Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for DiabetesShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina
  2. 2.Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South CampusShanghaiChina

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