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Science China Life Sciences

, Volume 61, Issue 6, pp 660–670 | Cite as

42,573 cases of hepatectomy in China: a multicenter retrospective investigation

  • Binhao Zhang
  • Bixiang Zhang
  • Zhiwei Zhang
  • Zhiyong Huang
  • Yifa Chen
  • Minshan Chen
  • Ping Bie
  • Baogang Peng
  • Liqun Wu
  • Zhiming Wang
  • Bo Li
  • Jia Fan
  • Lunxiu Qin
  • Ping Chen
  • Jingfeng Liu
  • Zhe Tang
  • Jun Niu
  • Xinmin Yin
  • Deyu Li
  • Songqing He
  • Bin Jiang
  • Yilei MaoEmail author
  • Weiping ZhouEmail author
  • Xiaoping ChenEmail author
Research Paper

Abstract

Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma (HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients, 81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein (AFP) level, and other 35% had an AFP level lower than 400 ng mL−1. In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was (191.7±105.6) min, the blood loss was (546.0±562.8) mL, and blood transfusion was (543.0±1,035.2) mL. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules, tumor thrombosis and high AFP level were risk factors that affect postoperative survival.

Keywords

hepatectomy hepatocellular carcinoma China 

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Notes

Acknowledgements

This work was supported by the State Key Project on Inflectional Disease of China (2012ZX10002016-004, 2012ZX 10002010-001-004), the Chinese Ministry of Public Health for Key Clinical Projects (439, 2010) to Prof. Xiaoping Chen, and the National Natural Science Foundation of China (81502524) to Dr. Binhao Zhang.

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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Binhao Zhang
    • 1
  • Bixiang Zhang
    • 1
  • Zhiwei Zhang
    • 1
  • Zhiyong Huang
    • 1
  • Yifa Chen
    • 1
  • Minshan Chen
    • 4
  • Ping Bie
    • 5
  • Baogang Peng
    • 6
  • Liqun Wu
    • 7
  • Zhiming Wang
    • 8
  • Bo Li
    • 9
  • Jia Fan
    • 10
  • Lunxiu Qin
    • 11
  • Ping Chen
    • 12
  • Jingfeng Liu
    • 13
  • Zhe Tang
    • 14
  • Jun Niu
    • 15
  • Xinmin Yin
    • 16
  • Deyu Li
    • 17
  • Songqing He
    • 18
  • Bin Jiang
    • 19
  • Yilei Mao
    • 3
    Email author
  • Weiping Zhou
    • 2
    Email author
  • Xiaoping Chen
    • 1
    Email author
  1. 1.Institute of Hepato-pancreato-bililary Surgery, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Eastern Hepatobiliary Surgery HospitalShanghaiChina
  3. 3.Union HospitalBeijingChina
  4. 4.Cancer Hospital of Sun Yat-sen UniversityGuangzhouChina
  5. 5.Southwest HospitalChongqingChina
  6. 6.The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina
  7. 7.Affiliated Hospital of Qingdao Medical CollegeQingdaoChina
  8. 8.Xiangya HospitalChangshaChina
  9. 9.West China HospitalChengduChina
  10. 10.Zhongshan Hospital of Fudan UniversityShanghaiChina
  11. 11.Huashan Hospital of Fudan UniversityShanghaiChina
  12. 12.Daping Hospitalthe Third Military Medical UniversityChongqingChina
  13. 13.Mengchao Hepatobiliary HospitalFuzhouChina
  14. 14.The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina
  15. 15.Qilu Hospital of Shandong UniversityJinanChina
  16. 16.Hunan People’s HospitalChangshaChina
  17. 17.Henan People’s HospitalZhengzhouChina
  18. 18.The First Affiliated Hospital of Guangxi Medical UniversityNanningChina
  19. 19.Taihe HospitalShiyanChina

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