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Science China Life Sciences

, Volume 62, Issue 1, pp 95–103 | Cite as

Whole body vibration with rest days could improve bone quality of distal femoral metaphysis by regulating trabecular arrangement

  • He GongEmail author
  • Rui Zhang
  • Jiazi Gao
  • Meng Zhang
  • Bei Liu
  • Min Zhang
  • Dong Zhu
Research Paper

Abstract

Low-magnitude, high-frequency vibration (LMHFV) with rest days (particularly seven rest days) was considerably effective in improving the morphological and mechanical properties of rat proximal femur. However, current knowledge is limited regarding the possible benefit of this mechanical regimen to other bone sites and whether the optimal rest days are the same. This study followed our previous experiment on LMHFV loading with rest days for three-month-old male Wistar rats. The experiment involved seven groups, namely, vibrational loading for X day followed with X day rest (X=1, 3, 5, 7), daily vibrational loading, tail suspension and baseline control. Micro-computed tomography (micro-CT) scanning was used to evaluate the microarchitecture of the distal femoral trabecular bone. Micro-CT image-based microfinite element analysis was performed for each distal femoral metaphysis. LMHFV with rest days substantially changed the trabecular arrangement from remarkably plate-like to rod-like. Vibrational loading with 1 day rest was substantially effective in improving the architecture and apparent- and tissuelevel mechanical properties of the rat distal femoral metaphysis. This study may provide an improved understanding of the sitespecific responses of bone tissue to LMHFV with rest days for a substantially effective therapy of a targeted bone site.

Keywords

low-magnitude high-frequency vibration rest days microarchitecture microfinite element analysis von Mises stress apparent stiffness distal femoral metaphysis 

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Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (81471753, 11432016, 11322223) and the Science and Technology Development Plan Projects of Jilin province (20160101297JC, 20170519008JH, 20170520093JH).

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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • He Gong
    • 1
    Email author
  • Rui Zhang
    • 1
    • 4
  • Jiazi Gao
    • 2
  • Meng Zhang
    • 2
  • Bei Liu
    • 2
  • Min Zhang
    • 2
  • Dong Zhu
    • 3
  1. 1.School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina
  2. 2.Department of Engineering MechanicsJilin UniversityChangchunChina
  3. 3.Department of OrthopaedicsNo. 1 Hospital of Jilin UniversityChangchunChina
  4. 4.National Research Center for Rehabilitation Technical AidsBeijingChina

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