Science China Life Sciences

, Volume 61, Issue 7, pp 779–786 | Cite as

Long-term follow-up of the effects of fecal microbiota transplantation in combination with soluble dietary fiber as a therapeutic regimen in slow transit constipation

  • Xueying Zhang
  • Hongliang Tian
  • Lili Gu
  • Yongzhan Nie
  • Chao Ding
  • Xiaolong Ge
  • Bo Yang
  • Jianfeng GongEmail author
  • Ning LiEmail author
Research Paper


As some studies have reported that strategies targeting the gut microbiota such as fecal microbiota transplantation (FMT) with or without other microecological therapy might have efficacy in treating slow transit constipation (STC), we conducted a single-center, open-label trial to study the long-term effect of FMT combined with soluble dietary fiber (pectin) on STC. Thirty-one adult patients with STC were enrolled into the trial. Patients received 6-day FMT procedures repeatedly for the first 3 months and soluble dietary fiber (pectin) daily during the follow-up. The rate of clinical remission and improvement, stool consistency, the Wexner constipation scale, and assessment of constipation-related symptoms were evaluated at week 4 and 1 year later. The clinical remission and improvement rates at week 4 were 69.0% (20/29) and 75.9% (22/29), respectively. At the end of the study, 48.3% (14/29) of patients continued to have at least three complete spontaneous bowel movements per week and 58.6% (17/29) of patients showed clinical improvements. Stool consistency, the Wexner constipation scale, and constipation symptoms improved both at short-term and long-term follow-up. The results indicated that FMT in combination with soluble dietary fiber (pectin) had both short-term and long-term efficacy in treating STC.


fecal microbiota transplantation soluble dietary fiber slow transit constipation long-term efficacy 


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We would like to thank Yue Hua, Yifan Zhu, Xuelei Zhang, Zhengjin Xie, Yan Zhou, Chunlian Ma and Lingling Huang from Jinling Hospital for their work in the collection of patients’ information. This work was supported by the National Natural Science Foundation of China (81670493) ( and by the National Gastroenterology Research Project (2015BAI13B07). We thank Kate Fox, DPhil, from Liwen Bianji, Edanz Group China (, for editing the English text of a draft of this manuscript. The funders had no role in study design, data collection and analysis, the decision to publish, or preparation of the manuscript.


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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Xueying Zhang
    • 1
  • Hongliang Tian
    • 2
  • Lili Gu
    • 1
  • Yongzhan Nie
    • 3
  • Chao Ding
    • 1
    • 4
  • Xiaolong Ge
    • 1
    • 5
  • Bo Yang
    • 2
  • Jianfeng Gong
    • 1
    Email author
  • Ning Li
    • 1
    • 2
    Email author
  1. 1.Department of General Surgery, Jinling HospitalMedical School of Nanjing UniversityNanjingChina
  2. 2.Shanghai Tenth People’s HospitalTenth People’s Hospital of Tongji UniversityShanghaiChina
  3. 3.Institute of Digestive Diseases, Xi Jing HospitalFourth Military Medical UniversityXi’anChina
  4. 4.Department of General Surgery, Drum Tower HospitalMedical School of Nanjing UniversityNanjingChina
  5. 5.Department of General Surgery, Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouChina

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