Science China Life Sciences

, Volume 60, Issue 9, pp 939–947 | Cite as

Biosynthesis and combinatorial biosynthesis of antifungal nucleoside antibiotics

  • Guoqing Niu
  • Jiazhen Zheng
  • Huarong TanEmail author


There is an urgent need for new antifungal agents to treat or combat fungal infection in humans and plants. Antifungal nucleoside antibiotics are an important family of natural products with distinctive structural features. Understanding their biosynthetic machinery is of great importance for the improvement of antibiotics titers. More importantly, it is a requisite for combinatorial biosynthesis to create hybrid nucleoside antibiotics. We herein focus on findings on the natural and designed biosynthesis of this important family of nucleoside antibiotics.


nucleoside antibiotics biosynthesis combinatorial biosynthesis 


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This work was supported by grants from the Ministry of Science and Technology of China (2013CB734001) and the National Natural Science Foundation of China (31470206 and 31571281).


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Copyright information

© Science China Press and Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.State Key Laboratory of Microbial Resources, Institute of MicrobiologyChinese Academy of SciencesBeijingChina
  2. 2.Biotechnology Research CenterSouthwest UniversityChongqingChina
  3. 3.University of Chinese Academy of SciencesBeijingChina

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