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Science China Life Sciences

, Volume 60, Issue 11, pp 1223–1233 | Cite as

Structural changes of gut microbiota in Parkinson’s disease and its correlation with clinical features

  • Wei Li
  • Xiaoli Wu
  • Xu Hu
  • Tao Wang
  • Shan Liang
  • Yunfeng Duan
  • Feng JinEmail author
  • Bin QinEmail author
Research Paper

Abstract

The aim of this study was to compare the structure of gut microbiota in Parkinson’s disease (PD) patients and healthy controls; and to explore correlations between gut microbiota and PD clinical features. We analyzed fecal bacterial composition of 24 PD patients and 14 healthy volunteers by using 16S rRNA sequencing. There were significant differences between PD and healthy controls, as well as among different PD stages. The putative cellulose degrading bacteria from the genera Blautia (P=0.018), Faecalibacterium (P=0.048) and Ruminococcus (P=0.019) were significantly decreased in PD compared to healthy controls. The putative pathobionts from the genera Escherichia-Shigella (P=0.038), Streptococcus (P=0.01), Proteus (P=0.022), and Enterococcus (P=0.006) were significantly increased in PD subjects. Correlation analysis indicated that disease severity and PD duration negatively correlated with the putative cellulose degraders, and positively correlated with the putative pathobionts. The results suggest that structural changes of gut microbiota in PD are characterized by the decreases of putative cellulose degraders and the increases of putative pathobionts, which may potentially reduce the production of short chain fatty acids, and produce more endotoxins and neurotoxins; and these changes is potentially associated with the development of PD pathology.

Keywords

microbiome α-synuclein gastrointestinal dysfunction gut-brain-axis 16S rRNA sequencing short chain fatty acids 

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Notes

Acknowledgements

This work was supported by Future Life Sciences International Ltd. (NSBJ01032014, http://flsi.jp/).

Supplementary material

11427_2016_9001_MOESM1_ESM.pdf (65 kb)
Rarefaction curves of Shannon index.
11427_2016_9001_MOESM2_ESM.pdf (474 kb)
Family level comparison.
11427_2016_9001_MOESM3_ESM.pdf (264 kb)
The heatmap based on the relative abundance of top 65 abundant genera.
11427_2016_9001_MOESM4_ESM.pdf (58 kb)
Significantly different genera between PD and HC groups
11427_2016_9001_MOESM5_ESM.pdf (34 kb)
Demographic characteristics of three groups
11427_2016_9001_MOESM6_ESM.pdf (60 kb)
Summary of clinical information between PD and HC groups

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Copyright information

© Science China Press and Springer-Verlag GmbH Heidelberg 2017

Authors and Affiliations

  1. 1.Key Laboratory of Mental Health, Institute of PsychologyChinese Academy of SciencesBeijingChina
  2. 2.University of Chinese Academy of SciencesBeijingChina
  3. 3.Department of NeurologyBeijing HospitalBeijingChina

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