Science China Life Sciences

, Volume 59, Issue 9, pp 977–978 | Cite as

Single-cell RNA-seq technology lends a hand into HSC ontogeny

  • Pengxu Qian
  • Linheng LiEmail author
Open Access
Research Highlight


  1. Ditadi, A., Sturgeon, C.M., Tober, J., Awong, G., Kennedy, M., Yzaguirre, A.D., Azzola, L., Ng, E.S., Stanley, E.G., French, D.L., Cheng, X., Gadue, P., Speck, N.A., Elefanty, A.G., and Keller, G. (2015). Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages. Nat Cell Biol 17, 580–591.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Qian, P., He, X.C., Paulson, A., Li, Z.R., Tao, F., Perry, J.M., Guo, F.L., Zhao, M., Zhi, L., Venkatraman, A., Haug, J.S., Parmely, T., Li, H., Dobrowsky, R.T., Ding, W.X., Kono, T., Ferguson-Smith, A.C., and Li, L.H. (2016). The dlk1-gtl2 locus preserves lt-hsc function by inhibiting the pi3k-mtor pathway to restrict mitochondrial metabolism. Cell Stem Cell 18, 214–228.CrossRefPubMedGoogle Scholar
  3. Orkin, S.H., and Zon, L.I. (2008). Hematopoiesis: An evolving paradigm for stem cell biology. Cell 132, 631–644.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Tang, F., Lao, K., and Surani, M.A. Development and applications of single-cell transcriptome analysis. Nat Methods 8, S6–S11.Google Scholar
  5. Zhou, F., Li, X., Wang, W., Zhu, P., Zhou, J., He, W.Y., Ding, M., Xiong, F.Y., Zheng, X.N., Li, Z., Ni, Y.L., Mu, X.H., Wen, L., Cheng, T., Lan, Y., Yuan, W.P., Tang, F,C., and Liu, B. (2016). Tracing haematopoietic stem cell formation at single-cell resolution. Nature 533, 487–492.CrossRefPubMedGoogle Scholar

Copyright information

© The Author(s) 2016

Authors and Affiliations

  1. 1.Stowers Institute for Medical ResearchKansas CityUSA
  2. 2.Department of Pathology and Laboratory MedicineUniversity of Kansas Medical CenterKansas CityUSA

Personalised recommendations