Science China Life Sciences

, Volume 59, Issue 7, pp 732–734 | Cite as

Unexpected complexity of multidrug resistance in the mcr-1-harbouring Escherichia coli

  • Rongsui Gao
  • Yue Li
  • Jingxia Lin
  • Chen TanEmail author
  • Youjun FengEmail author
Open Access
Letter to the Editor


Multidrug Resistance Colistin Polymyxin Macrodantin Aminoglycoside Antibiotic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Supplementary material

11427_2016_5070_MOESM1_ESM.docx (1.5 mb)
Supplementary material, approximately 1.50 MB.


  1. Du, H., Chen, L., Tang, Y.W., and Kreiswirth, B.N. (2016). Emergence of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae. Lancet Infect Dis 16, 287–288.CrossRefPubMedGoogle Scholar
  2. Hasman, H., Hammerum, A.M., Hansen, F., Hendriksen, R.S., Olesen, B., Agerso, Y., Zankari, E., Leekitcharoenphon, P., Stegger, M., Kaas, R.S., Cavaco, L.M., Hansen, D.S., Aarestrup, F.M., and Skov, R.L. (2015). Detection of mcr-1 encoding plasmid-mediated colistin-resistant Escherichia coli isolates from human bloodstream infection and imported chicken meat, Denmark 2015. Euro Surveill 20, ES.2015.20.49.30085.Google Scholar
  3. Liu, Y.Y., Wang, Y., Walsh, T.R., Yi, L.X., Zhang, R., Spencer, J., Doi, Y., Tian, G., Dong, B., Huang, X., Yu, L.F., Gu, D., Ren, H., Chen, X., Lv, L., He, D., Zhou, H., Liang, Z., Liu, J.H., and Shen, J. (2016). Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis 16, 161–168.CrossRefPubMedGoogle Scholar
  4. Nation, R.L., Li, J., Cars, O., Couet, W., Dudley, M.N., Kaye, K.S., Mouton, J.W., Paterson, D.L., Tam, V.H., Theuretzbacher, U., Tsuji, B.T., and Turnidge, J.D. (2015). Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus. Lancet Infect Dis 15, 225–234.CrossRefPubMedGoogle Scholar
  5. Paterson, D.L., and Harris, P.N. (2016). Colistin resistance: a major breach in our last line of defence. Lancet Infect Dis 16, 132–133.CrossRefPubMedGoogle Scholar
  6. Malhotra-Kumar, S., Xavier, B.B., Das, A.J., Lammens, C., Butaye, P., and Goossens, H. (2016). Colistin resistance gene mcr-1 harboured on a multidrug resistant plasmid. Lancet Infect Dis 16, 283–284.CrossRefPubMedGoogle Scholar
  7. Yao, X., Doi, Y., Zeng, L., Lv, L., and Liu, J.H. (2016). Carbapenemresistant and colistin-resistant Escherichia coli co-producing NDM-9 and MCR-1. Lancet Infect Dis 16, 288–289.CrossRefPubMedGoogle Scholar
  8. Ye, H., Li, Y., Li, Z., Gao, R., Zhang, H., Wen, R., Gao, G.F., Hu, Q., and Feng, Y. (2016). Diversified mcr-1-harbouring plasmid reservoirs confer resistance to colistin in human gut microbiota. MBio 7, pii: e00177–16. doi: 10.1128/mBio.00177-16CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  1. 1.Department of Medical Microbiology and ParasitologyZhejiang University School of MedicineHangzhouChina
  2. 2.State Key Laboratory of Agricultural Microbiology, College of Veterinary MedicineHuazhong Agricultural UniversityWuhanChina

Personalised recommendations