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Science China Life Sciences

, Volume 60, Issue 3, pp 326–328 | Cite as

Will cancer cells be defeated by sodium bicarbonate?

Research Highlight

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Notes

Acknowledgements

This work was supported by the Breast Cancer Research Foundation and the National Institutes of Health to Mark I. Greene (R01CA089481, R01CA149425), and the Department of Defense Lung Cancer Research Program Idea Development Award grant to Sunil Singhal (W81XWH-15-1-0362). Mr. Cameron Jeffers kindly read the manuscript and provided discussions and suggestions.

References

  1. Band, P.R., Maroun, J., Pritchard, K., Stewart, D., Coppin, C.M., Wilson, K., and Eisenhauer, E.A. (1986). Phase II study of lonidamine in patients with metastatic breast cancer: a National Cancer Institute of Canada Clinical Trials Group Study. Cancer Treat Rep 70, 1305–1310.PubMedGoogle Scholar
  2. Chao, M., Wu, H., Jin, K., Li, B., Wu, J., Zhang, G., Yang, G., and Hu, X. (2016). A nonrandomized cohort and a randomized study of local control of large hepatocarcinoma by targeting intratumoral lactic acidosis. eLife 5, e15691.CrossRefGoogle Scholar
  3. DeAngelo, A.B., Daniel, F.B., Stober, J.A., and Olson, G.R. (1991). The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouse. Fundam Appl Toxicol 16, 337–347.CrossRefPubMedGoogle Scholar
  4. Dorff, T.B., Groshen, S., Garcia, A., Shah, M., Tsao-Wei, D., Pham, H., Cheng, C.W., Brandhorst, S., Cohen, P., Wei, M., Longo, V., and Quinn, D.I. (2016). Safety and feasibility of fasting in combination with platinum- based chemotherapy. BMC Cancer 16, 360.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Ganapathy-Kanniappan, S., and Geschwind, J.F.H. (2013). Tumor glycolysis as a target for cancer therapy: progress and prospects. Mol Cancer 12, 152.CrossRefPubMedPubMedCentralGoogle Scholar
  6. He, Q., Lu, W.S., Liu, Y., Guan, Y.S., and Kuang, A.R. (2013). 131I-labeled metuximab combined with chemoembolization for unresectable hepatocellular carcinoma. World J Gastroenterol 19, 9104–9110.CrossRefPubMedPubMedCentralGoogle Scholar
  7. Marchiq, I., and Pouysségur, J. (2016). Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters. J Mol Med 94, 155–171.CrossRefPubMedGoogle Scholar
  8. Qorraj, M., Bruns, H., Böttcher, M., Weigand, L., Saul, D., Mackensen, A., Jitschin, R., and Mougiakakos, D. (2016). The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia. Leukemia in press doi: 10.1038/leu.2016.214.Google Scholar
  9. Schwartz, K., Chang, H.T., Nikolai, M., Pernicone, J., Rhee, S., Olson, K., Kurniali, P.C., Hord, N.G., and Noel, M. (2015). Treatment of glioma patients with ketogenic diets: report of two cases treated with an IRB-approved energy-restricted ketogenic diet protocol and review of the literature. Cancer Metab 3, 3.CrossRefPubMedPubMedCentralGoogle Scholar
  10. Wu, H., Ding, Z., Hu, D., Sun, F., Dai, C., Xie, J., and Hu, X. (2012). Central role of lactic acidosis in cancer cell resistance to glucose deprivationinduced cell death. J Pathol 227, 189–199.CrossRefPubMedGoogle Scholar

Copyright information

© Science in China Press and Springer-Verlag GmbH 2017

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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