Science China Life Sciences

, Volume 59, Issue 1, pp 93–96

Celebrating the work of Nobel Laureate Paul Modrich

Open Access
News And Views
  • 300 Downloads

References

  1. Aaltonen, L.A., Peltomäki, P., Leach, F.S., Sistonen, P., Pylkkänen, L., Mecklin, J.-P., Järvinen, H., Powell, S.M., Jen, J., Hamilton, S.R., Petersen, G.M., Kinzler, K.W., Vogelstein, B., and Delachapelle, A. (1993). Clues to the pathogenesis of familial colorectal cancer. Science 260, 812–816.CrossRefPubMedGoogle Scholar
  2. Allen, D.J., Makhov, A., Grilley, M., Taylor, J., Thresher, R., Modrich, P., and Griffith, J.D. (1997). MutS mediates heteroduplex loop formation by a translocation mechanism. EMBO J 16, 4467–4476.PubMedCentralCrossRefPubMedGoogle Scholar
  3. Au, K.G., Welsh, K., and Modrich, P. (1992). Initiation of methyl-directed mismatch repair. J Biol Chem 267, 12142–12148.PubMedGoogle Scholar
  4. Bronner, C.E., Baker, S.M., Morrison, P.T., Warren, G., Smith, L.G., Lescoe, M.K., Kane, M., Earabino, C., Lipford, J., Lindblom, A., Tanergard, P., Bollag, R.J., Godwin, A.R., Ward, D.C., Nordenskjold M., Fishel, R., Kolodner, R., and Liskay, R.M. (1994). Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368, 258–261.CrossRefPubMedGoogle Scholar
  5. Constantin, N., Dzantiev, L., Kadyrov, F.A., and Modrich, P. (2005). Human mismatch repair: Reconstitution of a nick-directed bidirectional reaction. J Biol Chem 280, 39752–39761.PubMedCentralCrossRefPubMedGoogle Scholar
  6. Cooper, D.L., Lahue, R.S., and Modrich, P. (1993). Methyl-directed mismatch repair is bidirectional. J Biol Chem 268, 11823–11829.PubMedGoogle Scholar
  7. Dao, V., and Modrich, P. (1998). Mismatch-, MutS-, MutL-, and helicase II-dependent unwinding from the single-strand break of an incised heteroduplex. J Biol Chem 273, 9202–9207.CrossRefPubMedGoogle Scholar
  8. Drummond, J.T., Li, G.M., Longley, M.J., and Modrich, P. (1995). Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science 268, 1909–1912.CrossRefPubMedGoogle Scholar
  9. Dzantiev, L., Constantin, N., Genschel, J., Iyer, R.R., Burgers, P.M., and Modrich, P. (2004). A defined human system that supports bidirectional mismatch-provoked excision. Mol cell 15, 31–41.CrossRefPubMedGoogle Scholar
  10. Fishel, R., Lescoe, M.K., Rao, M.R., Copeland, N.G., Jenkins, N.A., Garber, J., Kane, M., and Kolodner, R. (1993). The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75, 1027–1038.CrossRefPubMedGoogle Scholar
  11. Genschel, J., Bazemore, L.R., and Modrich, P. (2002). Human exonuclease I is required for 5' and 3' mismatch repair. J Biol Chem 277, 13302–13311.CrossRefPubMedGoogle Scholar
  12. Genschel, J., Littman, S.J., Drummond, J.T., and Modrich, P. (1998). Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. J Biol Chem 273, 19895–19901.CrossRefPubMedGoogle Scholar
  13. Grilley, M., Griffith, J., and Modrich, P. (1993). Bidirectional excision in methyl-directed mismatch repair. J Biol Chem 268, 11830–11837.PubMedGoogle Scholar
  14. Grilley, M., Holmes, J., Yashar, B., and Modrich, P. (1990). Mechanisms of DNA-mismatch correction. Mutat Res 236, 253–267.CrossRefPubMedGoogle Scholar
  15. Grilley, M., Welsh, K.M., Su, S.S., and Modrich, P. (1989). Isolation and characterization of the Escherichia coli mutL gene product. J Biol Chem 264, 1000–1004.PubMedGoogle Scholar
  16. Holmes, J., Jr., Clark, S., and Modrich, P. (1990). Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. Proc Natl Acad Sci USA 87, 5837–5841.PubMedCentralCrossRefPubMedGoogle Scholar
  17. Ionov, Y., Peinado, M.A., Malkhosyan, S., Shibata, D., and Perucho, M. (1993). Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363, 558–561.CrossRefPubMedGoogle Scholar
  18. Kadyrov, F.A., Dzantiev, L., Constantin, N., and Modrich, P. (2006). Endonucleolytic function of MutLalpha in human mismatch repair. Cell 126, 297–308.CrossRefPubMedGoogle Scholar
  19. Kolodner, R.D., Hall, N.R., Lipford, J., Kane, M.F., Rao, M.R., Morrison, P., Wirth, L., Finan, P.J., Burn, J., Chapman, P., Earabino C., Merchant, E., and Bishop, D.T. (1994). Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations. Genomics 24, 516–526.CrossRefPubMedGoogle Scholar
  20. Koshland, D.E., Jr. (1994). Molecule of the year: the DNA repair enzyme. Science 266, 1925.CrossRefPubMedGoogle Scholar
  21. Lahue, R.S., Au, K.G., and Modrich, P. (1989). DNA mismatch correction in a defined system. Science 245, 160–164.CrossRefPubMedGoogle Scholar
  22. Leach, F.S., Nicolaides, N.C., Papadopoulos, N., Liu, B., Jen, J., Parsons, R., Peltomaki, P., Sistonen, P., Aaltonen, L.A., Nystrom, L.M., Guan, X.Y., Zhang, J., Meltzer, P.S., Yu, J.W., Kao, F.T, Chen, D.J., Cerosaletti, K.M., Fournier, R.E.K., Todd, S., Lewis, T., Leach, R.J., Naylor, S.L., Weissenbach, J., Mecklin, J.P., Jarvinen, H., Petersen, G.M., Hamilton, S.R., Green, J., Jass, J., Watson, P., Lynch, H.T., Trent, J.M., Delachapelle, A., Kinzler, K.W., and Vogelstein, B. (1993). Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75, 1215–1225.CrossRefPubMedGoogle Scholar
  23. Levinson, G., and Gutman, G.A. (1987a). High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 in Escherichia coli K-12. Nucleic Acids Res 15, 5323–5338.PubMedCentralCrossRefPubMedGoogle Scholar
  24. Levinson, G., and Gutman, G.A. (1987b). Slipped-strand mispairing: A major mechanism for DNA sequence evolution. Mol Biol Evol 4, 203–221.PubMedGoogle Scholar
  25. Li, G.M., and Modrich, P. (1995). Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. Proc Natl Acad Sci USA 92, 1950–1954.PubMedCentralCrossRefPubMedGoogle Scholar
  26. Longley, M.J., Pierce, A.J., and Modrich, P. (1997). DNA polymerase delta is required for human mismatch repair in vitro. J Biol Chem 272, 10917–10921.CrossRefPubMedGoogle Scholar
  27. Lu, A.L., Clark, S., and Modrich, P. (1983). Methyl-directed repair of DNA base-pair mismatches in vitro. Proc Natl Acad Sci USA 80, 4639–4643.PubMedCentralCrossRefPubMedGoogle Scholar
  28. Marinus, M.G. (1976). Adenine methylation of Okazaki fragments in Escherichia coli. J Bacteriol 128, 853–854.PubMedCentralPubMedGoogle Scholar
  29. Modrich, P., Anraku, Y., and Lehman, I.R. (1973). Deoxyribonucleic acid ligase. Isolation and physical characterization of the homogeneous enzyme from Escherichia coli. J Biol Chem 248, 7495–7501.PubMedGoogle Scholar
  30. Modrich, P., and Lehman, I.R. (1970). Enzymatic joining of polynucleotides. IX. A simple and rapid assay of polynucleotide joining (ligase) activity by measurement of circle formation from linear deoxyadenylate-deoxythymidylate copolymer. J Biol Chem 245, 3626–3631.PubMedGoogle Scholar
  31. Modrich, P., and Lehman, I.R. (1971). Enzymatic characterization of a mutant of Escherichia coli with an altered DNA ligase. Proc Natl Acad Sci USA 68, 1002–1005.PubMedCentralCrossRefPubMedGoogle Scholar
  32. Modrich, P., Lehman, I.R., and Wang, J.C. (1972). Enzymatic joining of polynucleotides. XI. Reversal of Escherichia coli deoxyribonucleic acid ligase reaction. J Biol Chem 247, 6370–6372.PubMedGoogle Scholar
  33. Modrich, P., and Richardson, C.C. (1975a). Bacteriophage T7 Deoxyribonucleic acid replication in vitro. A protein of Escherichia coli required for bacteriophage T7 DNA polymerase activity. J Biol Chem 250, 5508–5514.PubMedGoogle Scholar
  34. Modrich, P., and Richardson, C.C. (1975b). Bacteriophage T7 deoxyribonucleic acid replication in vitro. Bacteriophage T7 DNA polymerase: an an emzyme composed of phage- and host-specific subunits. J Biol Chem 250, 5515–5522.PubMedGoogle Scholar
  35. Nicolaides, N.C., Papadopoulos, N., Liu, B., Wei, Y.-F., Carter, K.C., Ruben, S.M., Rosen, C.A., Haseltine, W.A., Fleischmann, R.D., Fraser, C.M., Adams M.D., Venter, J.C., Dunlop, M.G., Hamilton, S.R., Petersen, G.M., Delachapelle, A., Vogelstein, B. and Kinzler, K.W. (1994). Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature 371, 75–80.CrossRefPubMedGoogle Scholar
  36. Papadopoulos, N., Nicolaides, N.C., Wei, Y.F., Ruben, S.M., Carter, K.C., Rosen, C.A., Haseltine, W.A., Fleischmann, R.D., Fraser, C.M., Adams, M.D., Venter, J.C., Hamilton, S.R., Petersen, G.M., Watson, P., Lynch, H.T., Peltomaki, P., Mecklin, J.P., Delachapelle, A., Kinzler, K.W. and Vogelsstein, B. (1994). Mutation of a mutL homolog in hereditary colon cancer. Science 263, 1625–1629.CrossRefPubMedGoogle Scholar
  37. Parsons, R., Li, G.M., Longley, M.J., Fang, W.H., Papadopoulos, N., Jen, J., de la Chapelle, A., Kinzler, K.W., Vogelstein, B., and Modrich, P. (1993). Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell 75, 1227–1236.CrossRefPubMedGoogle Scholar
  38. Pukkila, P.J., Peterson, J., Herman, G., Modrich, P., and Meselson, M. (1983). Effects of high levels of DNA adenine methylation on methyl-directed mismatch repair in Escherichia coli. Genetics 104, 571–582.PubMedCentralPubMedGoogle Scholar
  39. Su, S.S., and Modrich, P. (1986). Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs. Proc Natl Acad Sci USA 83, 5057–5061.PubMedCentralCrossRefPubMedGoogle Scholar
  40. Thibodeau, S.N., Bren, G., and Schaid, D. (1993). Microsatellite instability in cancer of the proximal colon. Science 260, 816–819.CrossRefPubMedGoogle Scholar
  41. Wagner, R., Jr., and Meselson, M. (1976). Repair tracts in mismatched DNA heteroduplexes. Proc Natl Acad Sci USA 73, 4135–4139.PubMedCentralCrossRefPubMedGoogle Scholar
  42. Welsh, K.M., Lu, A.L., Clark, S., and Modrich, P. (1987). Isolation and characterization of the Escherichia coli mutH gene product. J Biol Chem 262, 15624–15629.PubMedGoogle Scholar
  43. Worth, L., Jr., Clark, S., Radman, M., and Modrich, P. (1994). Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs. Proc Natl Acad Sci USA 91, 3238–3241.PubMedCentralCrossRefPubMedGoogle Scholar
  44. Yamaguchi, M., Dao, V., and Modrich, P. (1998). MutS and MutL activate DNA helicase IIin a mismatch-dependent manner. J Biol Chem 273, 9197–9201.CrossRefPubMedGoogle Scholar

Copyright information

© The Author(s) 2016

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California Keck School of MedicineUniversity of Southern CaliforniaLos AngelesUSA

Personalised recommendations