Science China Life Sciences

, Volume 59, Issue 1, pp 103–105

The 2015 Albert Lasker Basic Medical Research Award: An exhilarating journey to the DNA damage checkpoint

Open Access
News And Views


  1. Durfee, T., Becherer, K., Chen, P.L., Yeh, S.H., Yang, Y., Kilburn, A.E., Lee, W.H., and Elledge, S.J. (1993). The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev 7, 555–569.CrossRefPubMedGoogle Scholar
  2. Elledge, S.J. (1996). Cell cycle checkpoints: preventing an identity crisis. Science 274, 1664–1672.CrossRefPubMedGoogle Scholar
  3. Elledge, S.J. (2015). Accidents and damage control. Cell 162, 1196–1200.CrossRefPubMedGoogle Scholar
  4. Elledge, S.J., and Davis, R.W. (1989). DNA damage induction of ribonucleotide reductase. Mol Cell Biol 9, 4932–4940.PubMedCentralCrossRefPubMedGoogle Scholar
  5. Elledge, S.J., and Walker, G.C. (1983a). The muc genes of pKM101 are induced by DNA damage. J Bacteriol 155, 1306–1315.PubMedCentralPubMedGoogle Scholar
  6. Elledge, S.J., and Walker, G.C. (1983b). Proteins required for ultraviolet light and chemical mutagenesis. Identification of the products of the umuC locus of Escherichia coli. J Mol Biol 164, 175–192.CrossRefPubMedGoogle Scholar
  7. Friedberg, E.C. (1997). Correcting the blueprint of life: An historical account of the discovery of DNA repair mechanisms (Cold Spring Harbor Laboratory Press).Google Scholar
  8. Hershey, A.D., and Chase, M. (1952). Independent functions of viral protein and nucleic acid in growth of bacteriophage. J Gen Physiol 36, 39–56.PubMedCentralCrossRefPubMedGoogle Scholar
  9. Kelner, A. (1949). Effect of visible light on the recovery of Streptomyces Griseus Conidia from Ultra-violet irradiation injury. Proc Natl Acad Sci USA 35, 73–79.PubMedCentralCrossRefPubMedGoogle Scholar
  10. Sanchez, Y., Desany, B.A., Jones, W.J., Liu, Q., Wang, B., and Elledge, S.J. (1996). Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271, 357–360.CrossRefPubMedGoogle Scholar
  11. Sanchez, Y., Wong, C., Thoma, R.S., Richman, R., Wu, Z., Piwnica-Worms, H., and Elledge, S.J. (1997). Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25. Science 277, 1497–1501.CrossRefPubMedGoogle Scholar
  12. Xu, G.J., Kula, T., Xu, Q., Li, M.Z., Vernon, S.D., Ndung'u, T., Ruxrungtham, K., Sanchez, J., Brander, C., Chung, R.T., O'Connor, K.C., Walker, B., Larman, H.B., Elledge, S.J. (2015). Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome. Science 348, aaa0698.Google Scholar
  13. Zhou, Z., and Elledge, S.J. (1993). DUN1 encodes a protein kinase that controls the DNA damage response in yeast. Cell 75, 1119–1127.CrossRefPubMedGoogle Scholar
  14. Zou, L., and Elledge, S.J. (2003). Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300, 1542–1548CrossRefPubMedGoogle Scholar

Copyright information

© The Author(s) 2016

Authors and Affiliations

  1. 1.Massachusetts General Hospital Cancer CenterHarvard Medical SchoolBostonUSA
  2. 2.Department of Pathology, Massachusetts General HospitalHarvard Medical SchoolBostonUSA
  3. 3.The University of Texas M. D. Anderson Cancer CenterDepartment of Experimental Radiation OncologyHoustonUSA

Personalised recommendations