Science China Life Sciences

, Volume 57, Issue 9, pp 957–958 | Cite as

Biased ligand bonds to make right calls—laboratory of signal transduction reveals molecular mechanism for functional selectivity of GPCR

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References

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    Woo AY, Jozwiak K, Toll L, Tanga MJ, Kozocas JA, Jimenez L, Huang Y, Song Y, Plazinska A, Pajak K, Paul RK, Bernier M, Wainer IW, Xiao RP. Tyrosine 308 is necessary for ligand-directed Gs-biased signaling of β2-adrenoceptor. J Biol Chem, 2014, doi: 10.1074/jbc.M114.558882Google Scholar
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    Xiao RP, Zhang SJ, Chakir K, Avdonin P, Zhu W, Bond RA, Balke CW, Lakatta EG, Cheng H. Enhanced G(i) signaling selectively negates β2-adrenergic receptor (AR)—but not β1-AR-mediated positive inotropic effect in myocytes from failing rat hearts. Circulation, 2003, 108:1633–1639PubMedCrossRefGoogle Scholar

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© The Author(s) 2014

Authors and Affiliations

  1. 1.Institute of Molecular MedicinePeking UniversityBeijingChina

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