Science China Life Sciences

, Volume 56, Issue 8, pp 701–710 | Cite as

Duck egg drop syndrome virus: an emerging Tembusu-related flavivirus in China

  • PeiPei Liu
  • Hao Lu
  • Shuang Li
  • Ying Wu
  • George Fu Gao
  • JingLiang Su
Open Access
Review Special Topic: Haunted with and Hunting for Viruses / Progress of Projects Supported by NSFC


Duck egg drop syndrome virus (DEDSV) is a newly emerging pathogenic flavivirus isolated from ducks in China. DEDSV infection mainly results in severe egg drop syndrome in domestic poultry, which leads to huge economic losses. Thus, the discovery of ways and means to combat DEDSV is urgent. Since 2010, a remarkable amount of progress concerning DEDSV research has been achieved. Here, we review current knowledge on the epidemiology, symptomatology, and pathology of DEDSV. A detailed dissection of the viral genome and polyprotein sequences, comparative analysis of viral antigenicity and the corresponding potential immunity against the virus are also summarized. Current findings indicate that DEDSV should be a distinct species from Tembusu virus. Moreover, the adaption of DEDSV in wildlife and its high homology to pathogenic flaviviruses (e.g., West Nile virus, Japanese encephalitis virus, and dengue virus), illustrate its reemergence and potential to become a zoonotic pathogen that should not be overlooked. Detailed insight into the antigenicity and corresponding immunity against the virus is of clear significance for the development of vaccines and antiviral drugs specific for DEDSV.


DEDSV BYDV pathology genome phylogeny antigenicity vaccine 


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Copyright information

© The Author(s) 2013

Authors and Affiliations

  1. 1.CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of MicrobiologyChinese Academy of SciencesBeijingChina
  2. 2.Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary MedicineChina Agricultural UniversityBeijingChina
  3. 3.Bureau of Life Sciences and BiotechnologyChinese Academy of SciencesBeijingChina
  4. 4.University of Chinese Academy of SciencesBeijingChina
  5. 5.National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina
  6. 6.Research Network of Immunity and Health, Beijing Institutes of Life ScienceChinese Academy of SciencesBeijingChina

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