Green tea catechins prevent obesity through modulation of peroxisome proliferator-activated receptors
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Epidemiological evidence and experimental studies suggest that drinking green tea is associated with a lower risk of obesity and related diseases. However, the mechanisms of these effects are not clear. In the present study, we investigated the anti-obesity mechanisms of green tea catechins (GTCs) through modulation of peroxisome proliferator activated-receptor (PPAR) pathways in high-fat diet-induced obesity in rats. GTC supplementation significantly attenuated the increased body and liver weights and the elevated serum and liver triglyceride levels. Meanwhile, GTCs increased the PPARγ levels in subcutaneous white adipose tissue (SWAT) and decreased the PPARγ levels in visceral white adipose tissue (VWAT). In addition, GTC treatment up-regulated the levels of PPARδ in SWAT, VWAT, and brown adipose tissue and increased the expression of genes involved in fatty acid oxidation in brown adipose tissue. Our results suggest that GTCs exert their anti-obesity mechanism in part by modulating PPAR signaling pathways.
Keywordsobesity green tea catechins peroxisome proliferator activated-receptors (PPARs) hyperlipidemia metabolic syndrome
- 1.National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults—the evidence report. Obes Res, 1998, 6(Suppl 2): 51S–209SGoogle Scholar
- 17.Mukherjee R, Jow L, Croston G E, et al. Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists. J Biol Chem, 1997, 272: 8071–8076PubMedCrossRefGoogle Scholar
- 24.DeFronzo R A. Dysfunctional fat cells, lipotoxicity and type 2 diabetes. Int J Clin Pract Suppl, 2004, 9–21Google Scholar