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Science China Life Sciences

, Volume 56, Issue 9, pp 804–810 | Cite as

Green tea catechins prevent obesity through modulation of peroxisome proliferator-activated receptors

  • JingQi Yan
  • Yan Zhao
  • BaoLu ZhaoEmail author
Open Access
Research Paper Progress of Projects Supported by NSFC

Abstract

Epidemiological evidence and experimental studies suggest that drinking green tea is associated with a lower risk of obesity and related diseases. However, the mechanisms of these effects are not clear. In the present study, we investigated the anti-obesity mechanisms of green tea catechins (GTCs) through modulation of peroxisome proliferator activated-receptor (PPAR) pathways in high-fat diet-induced obesity in rats. GTC supplementation significantly attenuated the increased body and liver weights and the elevated serum and liver triglyceride levels. Meanwhile, GTCs increased the PPARγ levels in subcutaneous white adipose tissue (SWAT) and decreased the PPARγ levels in visceral white adipose tissue (VWAT). In addition, GTC treatment up-regulated the levels of PPARδ in SWAT, VWAT, and brown adipose tissue and increased the expression of genes involved in fatty acid oxidation in brown adipose tissue. Our results suggest that GTCs exert their anti-obesity mechanism in part by modulating PPAR signaling pathways.

Keywords

obesity green tea catechins peroxisome proliferator activated-receptors (PPARs) hyperlipidemia metabolic syndrome 

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Copyright information

© The Author(s) 2013

Authors and Affiliations

  1. 1.State Key Laboratory of Brain & Cognitive Sciences, Institute of BiophysicsChinese Academy of SciencesBeijingChina
  2. 2.Department of Food Sciences and TechnologyHarbin Institute of Technology at WeihaiWeihaiChina

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