Science China Life Sciences

, Volume 53, Issue 2, pp 183–189 | Cite as

Structural immunology of costimualtory and coinhibitory molecules

  • ShengDian WangEmail author
  • LiePing Chen
Special Topic Review


The T cell costimulatory pathways are central to regulating immune responses, and targeting these pathways represents one of the most promising approaches for achieving immunotherapy. The molecular structures of costimulation revealed invaluable mechanistic insights underlying costimulatory receptor/ligand specificity, affinity, oligomeric state, and valency, which provided the bases for better manipulation of these signaling pathways. The incredible growth of this field led to identification of new members and unexpected interactions, revealing a complicated regulatory network of immune responses. The advances in structural biology of costimulation will promise unprecedented opportunities for furthering our understanding and therapeutic application of T cell costimulatory pathways.


costimulatory molecules T cells molecular structure immunotherapy 


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Copyright information

© Science in China Press and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Center for Infection and Immunity, Institute of BiophysicsChinese Academy of SciencesBeijingChina
  2. 2.Department of OncologyJohns Hopkins University School of MedicineBaltimoreUSA

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