Science China Life Sciences

, Volume 53, Issue 1, pp 101–106

microRNA-181b targets MLK2 in HL-60 cells

Research Paper

DOI: 10.1007/s11427-010-0002-y

Cite this article as:
Chen, H., Chen, Q., Fang, M. et al. Sci. China Life Sci. (2010) 53: 101. doi:10.1007/s11427-010-0002-y

Abstract

microRNAs (miRNAs) play critical roles in many different cellular processes, including metabolism, apoptosis, differentiation and development. We showed miR-181b to be highly expressed in acute myeloid leukemia (AML). Furthermore, miR-181b contributed to proliferation of AML cells by targeting MLK2. Our results demonstrated that miR-181b plays an important role in the biology of AML and may be useful in developing therapies targeting miRNAs.

Keywords

microRNA-181b MLK2 AML HL-60 proliferation apoptosis 

Copyright information

© Science in China Press and Springer Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.The First Affiliated Hospital of Harbin Medical UniversityHarbinChina
  2. 2.Harbin Acheng District People’s HospitalHarbinChina
  3. 3.Graduate department of Harbin Medical UniversityHarbinChina

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