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Science China Chemistry

, Volume 62, Issue 11, pp 1463–1475 | Cite as

Recent advances in radical-mediated [2+2+m] annulation of 1,n-enynes

  • Chong-Hui Xu
  • Yang Li
  • Jin-Heng LiEmail author
  • Jian-Nan Xiang
  • Wei DengEmail author
Reviews

Abstract

1,n-Enynes are a versatile class of unsaturated hydrocarbons that find broad applications in the synthetic community of natural products, biologically active structures and functional materials. Typical methods for the transformations of 1,n-enynes include the radical-mediated [2+2+m] annulation reaction as they are particularly efficient accesses to functionalized polycyclic compounds. We herein highlighted recent process in the radical-mediated [2+2+m] annulation of 1,n-enynes, including [2+2+1] and [2+2+2] modes, for the construction of five- to six-membered-ring-fused polycyclic scaffolds. Meanwhile, the mechanisms for these transformations were described.

Keywords

radical annulation oxidants 1,n-enynes polycycles 

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Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (21625203, 21871126) and the Jiangxi Province Science and Technology Project (20182BCB22007).

Conflict of interest The authors declare that they have no conflict of interest.

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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical EngineeringHunan UniversityChangshaChina
  2. 2.Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources RecycleNanchang Hangkong UniversityNanchangChina

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