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Science China Chemistry

, Volume 62, Issue 11, pp 1501–1503 | Cite as

Synthesis of 1,3-benzothiazines by intramolecular dehydrogenative C–S cross-coupling in a flow electrolysis cell

  • Chong Huang
  • Hai-Chao XuEmail author
Communications
  • 234 Downloads

Abstract

Dehydrogenative cyclization of thioamides is an attractive approach for the synthesis of S-heterocycles. Reported herein is an electrochemical dehydrogenative cyclization reaction of N-benzyl thioamides in a flow electrolysis cell. The continuous-flow electrosynthesis has addressed the limitations associated with previously reported methods for the cyclization of alkylthioamides and provide a transition metal- and oxidizing reagent-free access to various functionalized 1,3-benzothiazines in good yields.

Keywords

C-H functionalization electrochemistry flow chemistry heterocycles 

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Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (21672178) and Fundamental Research Funds for the Central Universities.

Conflict of interest The authors declare that they have no conflict of interest.

Supplementary material

11426_2019_9554_MOESM1_ESM.pdf (5 mb)
Supporting Information

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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Physical Chemistry of Solid Surfaces, Innovative Collaboration Center of Chemistry for Energy Materials, Key Laboratory of Chemical Biology of Fujian Province, College of Chemistry and Chemical EngineeringXiamen UniversityXiamenChina

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