Science China Chemistry

, Volume 62, Issue 11, pp 1492–1496 | Cite as

Nickel-catalyzed reductive coupling of glucosyl halides with aryl/vinyl halides enabling β-selective preparation of C-aryl/vinyl glucosides

  • Jiandong Liu
  • Chuanhu LeiEmail author
  • Hegui GongEmail author


This work describes stereoselective preparation of β-C-aryl/vinyl glucosides via mild Ni-catalyzed reductive arylation and vinylation of C1-glucosyl halides with aryl and vinyl halides. A broad range of aryl halides and vinyl halides were employed to yield C-aryl/vinyl glucosides in 42%–93% yields. Good to excellent β-selectivities were obtained for C-glucosides by using tridentate ligand.


nickel-catalyzed reductive coupling β-selective preparation C-aryl/vinyl glucosides 


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This work was supported by the National Natural Science Foundation of China (21871173, 21572140, 21372151).

Conflict of interest The authors declare that they have no conflict of interest.

Supplementary material

11426_2019_9501_MOESM1_ESM.pdf (5.1 mb)
Stereoselective Preparation of β-C-Aryl/Vinyl Glucosides via Nickel-Catalyzed Reductive Couplings


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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.School of Materials Science and Engineering, Center for Supramolecular Chemistry and Catalysis, Department of ChemistryShanghai UniversityShanghaiChina

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