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Science China Chemistry

, Volume 61, Issue 12, pp 1503–1552 | Cite as

Precise nanomedicine for intelligent therapy of cancer

  • Huabing Chen
  • Zhanjun Gu
  • Hongwei An
  • Chunying Chen
  • Jie Chen
  • Ran Cui
  • Siqin Chen
  • Weihai Chen
  • Xuesi Chen
  • Xiaoyuan Chen
  • Zhuo Chen
  • Baoquan Ding
  • Qian Dong
  • Qin Fan
  • Ting Fu
  • Dayong Hou
  • Qiao Jiang
  • Hengte Ke
  • Xiqun Jiang
  • Gang Liu
  • Suping Li
  • Tianyu Li
  • Zhuang Liu
  • Guangjun Nie
  • Muhammad Ovais
  • Daiwen Pang
  • Nasha Qiu
  • Youqing Shen
  • Huayu Tian
  • Chao Wang
  • Hao Wang
  • Ziqi Wang
  • Huaping Xu
  • Jiang-Fei Xu
  • Xiangliang Yang
  • Shuang Zhu
  • Xianchuang Zheng
  • Xianzheng Zhang
  • Yanbing Zhao
  • Weihong TanEmail author
  • Xi ZhangEmail author
  • Yuliang ZhaoEmail author
Invited Reviews

Abstract

Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.

Keywords

nanomedicine nanoparticles cancer therapy cancer imaging intelligent therapy 

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (11621505, 11435002, 31671016).

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Copyright information

© Science in China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Huabing Chen
    • 1
  • Zhanjun Gu
    • 2
  • Hongwei An
    • 2
    • 3
  • Chunying Chen
    • 3
    • 4
  • Jie Chen
    • 5
    • 6
    • 7
  • Ran Cui
    • 8
  • Siqin Chen
    • 9
  • Weihai Chen
    • 10
  • Xuesi Chen
    • 5
    • 6
    • 7
  • Xiaoyuan Chen
    • 11
  • Zhuo Chen
    • 12
  • Baoquan Ding
    • 3
  • Qian Dong
    • 12
  • Qin Fan
    • 13
  • Ting Fu
    • 12
  • Dayong Hou
    • 3
  • Qiao Jiang
    • 3
  • Hengte Ke
    • 1
  • Xiqun Jiang
    • 14
  • Gang Liu
    • 15
  • Suping Li
    • 3
  • Tianyu Li
    • 16
  • Zhuang Liu
    • 13
  • Guangjun Nie
    • 3
  • Muhammad Ovais
    • 3
    • 4
  • Daiwen Pang
    • 8
  • Nasha Qiu
    • 9
  • Youqing Shen
    • 9
  • Huayu Tian
    • 5
    • 6
    • 7
  • Chao Wang
    • 13
  • Hao Wang
    • 3
  • Ziqi Wang
    • 3
  • Huaping Xu
    • 16
  • Jiang-Fei Xu
    • 16
  • Xiangliang Yang
    • 17
  • Shuang Zhu
    • 2
  • Xianchuang Zheng
    • 14
  • Xianzheng Zhang
    • 10
  • Yanbing Zhao
    • 17
  • Weihong Tan
    • 12
    • 18
    Email author
  • Xi Zhang
    • 16
    Email author
  • Yuliang Zhao
    • 3
    Email author
  1. 1.State Key Laboratory of Radiation Medicine and Protection, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical SciencesSoochow UniversitySuzhouChina
  2. 2.Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina
  3. 3.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijingChina
  4. 4.University of Chinese Academy of SciencesBeijingChina
  5. 5.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunChina
  6. 6.University of Science and Technology of ChinaHefeiChina
  7. 7.Jilin Biomedical Polymers Engineering LaboratoryChangchunChina
  8. 8.Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, State Key Laboratory of Virology, and Institute for Advanced StudiesWuhan UniversityWuhanChina
  9. 9.Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological EngineeringZhejiang UniversityHangzhouChina
  10. 10.Key Laboratory of Biomedical Polymers of Ministry of Education, Department of ChemistryWuhan UniversityWuhanChina
  11. 11.Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and BioengineeringNational Institutes of HealthBethesdaUSA
  12. 12.Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan ProvinceHunan UniversityChangshaChina
  13. 13.Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft MaterialsSoochow UniversitySuzhouChina
  14. 14.Department of Polymer Science and Engineering, College of Chemistry and Chemical EngineeringNanjing UniversityNanjingChina
  15. 15.State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public HealthXiamen UniversityXiamenChina
  16. 16.Department of ChemistryTsinghua UniversityBeijingChina
  17. 17.National Engineering Research Center for Nanomedicine, College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhanChina
  18. 18.Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at Bio/nano Interface, Health Cancer Center, UF Genetics Institute and McKnight Brain InstituteUniversity of FloridaGainesvilleUSA

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