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Value-added anticancer reactivity of sub-5 nm Ag-drug nanoparticles derived from organosilver(I) MOF

  • Chao-Yu Song
  • Jia-Yuan Zhang
  • Yuan Qiu
  • Hai-Ping Jin
  • Hui-Ming Zhang
  • Shuang Liu
  • Hong Liu
  • Hong-Bin Qiu
  • Guang-Gang Gao
Articles
  • 23 Downloads

Abstract

A totally structure-determined organosilver(I) metal-oganic framework (MOF) of [{Ag18(CF3COO)18(H2O)2}{Ag4(erlotinib)4}]n•7nCH3OH•3nH2O (1) was first synthesized by the self-assembly of erlotinib drug ligand and silver salts in the study. 1 formed a NbO-like 3D network, which was built from Ag(I)-erlotinib induced chains and 18-core silver(I) nanoclusters. When 1 was dispersed in methanol solution, it formed derivative nanoparticles (1-NPs) with the average size of 3.81 nm. Silver(I) ion is an efficient reactive oxygen species (ROS) evocator, whereas the erlotinib ligand possesses the targeting activity towards tumor cells. Therefore, IC50 values of 1-NPs for A549 and MRC-5 cells were respectively 0.97 and 7.28 μM, which were lower than IC50 value of erlotinib. It should be noted that the 7.5-fold higher inhibition effect on A549 cells allows 1-NPs to be a potential targeting anticancer drug for curing lung cancer. The study opens a new avenue to design anticancer drugs based on organosilver(I) MOF derivatives that can realize the value-added reactivity by combining clinical drugs with ROS-inductive silver(I) ion.

Keywords

erlotinib silver nanocluster targeting A549 cell supramolecular 

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Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (21271034, 31471312), the Heilongjiang Provincial Natural Science Foundation (B2017013), the Shandong Provincial Natural Science Foundation (ZR2017MEM003), the Principal Innovation and Entrepreneurship of Jiamusi University (XZYF2017-21), the Science and Technology Innovation Team Program of Jiamusi University (CXTD 2016-01), and Application Foundation and Advanced Technology Program of Jiamusi University (yzz2014-002).

Supplementary material

11426_2018_9376_MOESM1_ESM.doc (2.2 mb)
Value-added anticancer reactivity of sub-5nm Ag-drug nanoparticles derived from organosilver(I) MOF

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Copyright information

© Science in China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of Basic MedicineJiamusi UniversityJiamusiChina
  2. 2.School of Public HealthJiamusi UniversityJiamusiChina
  3. 3.School of Materials Science and EngineeringUniversity of JinanJinanChina

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