Science China Chemistry

, Volume 59, Issue 9, pp 1065–1078 | Cite as

Asymmetric construction of all-carbon quaternary stereocenters in the total synthesis of natural products

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Abstract

Structure units containing all-carbon quaternary stereogenic center are found in many bioactive natural products. However, enantioselective construction of this type of structure units has been a formidable challenge for synthetic community due to the steric hindrance enforced by all-carbon quaternary stereocenters. In this review, we present the achievements made by Chinese scientists in the area of asymmetric synthesis of all-carbon quaternary stereocenters in natural products during the past two years.

Keywords

all-carbon quaternary stereocenter asymmetric synthesis total synthesis natural product 
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Copyright information

© Science China Press and Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and TechnologyYunnan UniversityKunmingChina

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