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Science China Chemistry

, Volume 59, Issue 2, pp 180–183 | Cite as

Photoredox-catalyzed [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes in continuous flow

  • Jiang Wang
  • Theresa H. Nguyen
  • Nan ZhengEmail author
Articles SPECIAL TOPIC · Organic Photochemistry

Abstract

Continuous flow has recently emerged as a powerful enabling technology that greatly improves many reactions’ efficiency. Here, we apply the technology to intermolecular [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes by photoredox catalysis. An across-the-board improvement in the annulation’s efficiency is noticed. Moreover, a gram-scale annulation is successfully demonstrated in continuous flow using a much lower catalyst loading.

Keywords

photocatalysis continuous flow N-cyclobutylaniline [4+2] annulation visible light 

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Supplementary material

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Copyright information

© Science China Press and Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of Chemistry and BiochemistryUniversity of ArkansasFayettevilleUSA

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