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Cytotoxicity of mitochondrial-targeting silica-coated manganese oxide nanoparticles

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Abstract

The mitochondrion is a promising target for diagnosis and therapy. Mitochondrial-targeting silica-coated manganese oxide nanoparticles (MnO@SiO2-PPh3 + NPs) were successfully synthesized to explore the mitochondrial cytotoxicity of nanoparticles. The mitochondrial targeting property was confirmed by a laser scanning confocal microscopy experiment. Even after incubation for only 4 h, the cytotoxicity of MnO@SiO2-PPh3 + NPs against cancer cells was obvious; the ATP content was significantly decreased to 40%; and the mitochondrial membrane potential was depleted. All of these results indicated the collapse of mitochondrial function and the start of a cell apoptosis pathway. Our findings suggest that mitochondrial-mediated

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Authors and Affiliations

  1. The Key Laboratory of Resource Chemistry of Ministry of Education; Shanghai Key Laboratory of Rare Earth Functional Materials; Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234, China

    Jie Wei, Chao Yu, Li Wang, Jun Wang, Zhiguo Zhou, Hong Yang & Shiping Yang

Authors
  1. Jie Wei
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  2. Chao Yu
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  3. Li Wang
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  4. Jun Wang
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  5. Zhiguo Zhou
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  6. Hong Yang
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  7. Shiping Yang
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Correspondence to Hong Yang.

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Wei, J., Yu, C., Wang, L. et al. Cytotoxicity of mitochondrial-targeting silica-coated manganese oxide nanoparticles. Sci. China Chem. 58, 1537–1543 (2015). https://doi.org/10.1007/s11426-015-5374-1

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  • DOI: https://doi.org/10.1007/s11426-015-5374-1

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