Science China Chemistry

, Volume 53, Issue 9, pp 1899–1906

Nickel-catalyzed enantioselective hydrovinylation of silyl-protected allylic alcohols: An efficient access to homoallylic alcohols with a chiral quaternary center

  • Qi Zhang
  • Shou-Fei Zhu
  • Yan Cai
  • Li-Xin Wang
  • Qi-Lin Zhou
Articles

DOI: 10.1007/s11426-010-4036-6

Cite this article as:
Zhang, Q., Zhu, SF., Cai, Y. et al. Sci. China Chem. (2010) 53: 1899. doi:10.1007/s11426-010-4036-6

Abstract

Asymmetric hydrovinylation of silyl-protected allylic alcohols catalyzed by nickel complexes of chiral spiro phosphoramidite ligands was developed. A series of homoallylic alcohols with a chiral quaternary center were produced in high yields (up to 97%) and high enantioselectivities (up to 95% ee). The reaction provides an efficient method for preparing bifunctional compounds with a chiral quaternary carbon center.

Keywords

asymmetric hydrovinylation chiral spiro phosphorus ligands functionalized olefins chiral quaternary center 

Copyright information

© Science China Press and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Qi Zhang
    • 1
  • Shou-Fei Zhu
    • 1
  • Yan Cai
    • 1
  • Li-Xin Wang
    • 1
  • Qi-Lin Zhou
    • 1
  1. 1.State Key Laboratory and Institute of Elemento-organic ChemistryNankai UniversityTianjinChina

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