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Science China Chemistry

, Volume 53, Issue 1, pp 3–20 | Cite as

Carbohydrate biomarkers for future disease detection and treatment

  • YunFeng Cheng
  • MinYong Li
  • ShaoRu Wang
  • HanJing Peng
  • Suazette Reid
  • NanTing Ni
  • Hao Fang
  • WenFang Xu
  • BingHe Wang
Reviews

Abstract

Carbohydrates are considered as one of the most important classes of biomarkers for cell types, disease states, protein functions, and developmental states. Carbohydrate “binders” that can specifically recognize a carbohydrate biomarker can be used for developing novel types of site specific delivery methods and imaging agents. In this review, we present selected examples of important carbohydrate biomarkers and how they can be targeted for the development of therapeutic and diagnostic agents. Examples are arranged based on disease categories including (1) infectious diseases, (2) cancer, (3) inflammation and immune responses, (4) signal transduction, (5) stem cell transformation, (6) embryo development, and (7) cardiovascular diseases, though some issues cross therapeutic boundaries.

Keywords

carbohydrates biomarkers imaging agents boronolectins 

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Copyright information

© Science in China Press and Springer Berlin Heidelberg 2010

Authors and Affiliations

  • YunFeng Cheng
    • 1
  • MinYong Li
    • 2
  • ShaoRu Wang
    • 1
  • HanJing Peng
    • 1
  • Suazette Reid
    • 1
  • NanTing Ni
    • 1
  • Hao Fang
    • 2
  • WenFang Xu
    • 2
  • BingHe Wang
    • 1
  1. 1.Department of ChemistryGeorgia State UniversityAtlantaUSA
  2. 2.Department of Medicinal Chemistry, School of PharmacyShandong UniversityJinanChina

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