Forensic Toxicology

, Volume 34, Issue 1, pp 144–150 | Cite as

Identification and characterization of a novel cathinone derivative 1-(2,3-dihydro-1H-inden-5-yl)-2-phenyl-2-(pyrrolidin-1-yl)-ethanone seized by customs in Jersey

  • Lubertus Bijlsma
  • Bram Miserez
  • María Ibáñez
  • Cristian Vicent
  • Eva Guillamón
  • John Ramsey
  • Félix Hernández
Original Article

Abstract

A suspicious white powder labeled “idanyl-biphenyl-amninone,” which was seized by customs officials at the "channel island" of Jersey, UK, was brought to our laboratory for identification and characterization of its structure. The elucidation process required the use of several complementary analytical techniques, including gas chromatography–mass spectrometry, liquid chromatography coupled with high-resolution mass spectrometry, nuclear magnetic resonance spectroscopy, and X-ray crystallography. The unknown compound was ultimately identified as 1-(2,3-dihydro-1H-inden-5-yl)-2-phenyl-2-(pyrrolidin-1-yl)-ethanone, a novel cathinone derivative. To the best of our knowledge, this compound has not been registered in the CAS or IUPAC databases. However, it has recently been marketed on the Internet as “indapyrophenidone,” and we therefore propose this as the common name of the compound. The results of this study may serve forensic and clinical laboratories in the identification of its related compounds with similar backbone structure using the information reported in this article obtained by the application of advanced analytical techniques. It may also lead to timely and effective response on the part of legislators and law enforcement.

Keywords

New psychoactive substances Novel cathinone derivative 1-(2,3-Dihydro-1H-inden-5-yl)-2-phenyl-2-(pyrrolidin-1-yl)-ethanone Indapyrophenidone High-resolution mass spectrometry Nuclear magnetic resonance spectroscopy X-ray crystallography 

Supplementary material

11419_2015_299_MOESM1_ESM.docx (557 kb)
Supplementary material 1 (DOCX 556 kb)

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Copyright information

© Japanese Association of Forensic Toxicology and Springer Japan 2015

Authors and Affiliations

  • Lubertus Bijlsma
    • 1
  • Bram Miserez
    • 2
  • María Ibáñez
    • 1
  • Cristian Vicent
    • 3
  • Eva Guillamón
    • 4
  • John Ramsey
    • 2
  • Félix Hernández
    • 1
  1. 1.Research Institute for Pesticides and WaterUniversity Jaume ICastellónSpain
  2. 2.TICTAC Communications Ltd., St George’s University of LondonLondonUK
  3. 3.Serveis Centrals d’Instrumentacio CientíficaUniversitat Jaume ICastellónSpain
  4. 4.Department Química Física I AnalíticaUniversitat Jaume ICastellónSpain

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