Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and its related compounds. VI. Structure-analgesic activity relationship for fentanyl, methyl-substituted fentanyls and other analogues
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Eleven chemically modified 1-(2-phenethyl)-4-(N-propionylanilino)-piperidine (fentanyl) analogues were synthesized and their analgesic activities were evaluated by the acetic acid writhing method in mice. Their effective dose (ED50) and lethal dose (LD50) values were compared with those of morphine and fentanyl. The synthesized fentanyl analogues were categorized into three groups: a mono-methylated group, a group in which hydrogen in the para-position of the aromatic ring bound to the propionylanilino group was substituted with F, Cl, CH3, or OCH3, and a group in which the propionyl moiety was changed to an acetyl one. 3-Methylfentanyl showed the strongest analgesic activity among these compounds, and the most frequently abused fentanyl derivative, α-methylfentanyl, also showed quite strong activity. The analgesic activities of p-fluorofentanyl and acetylfentanyl were also relatively strong and not negligible. The activities of other analogues were significantly lower than that of fentanyl. The ranges between LD50 and ED50 of these fentanyl analogues were narrower than that of fentanyl. A number of fatal cases in humans caused by the abuse of fentanyl analogues are considered to be due not only to overdosing but also to the narrow ranges between the ED50 and LD50 values.
KeywordsFentanyl α-Methylfentanyl 3-Methylfentanyl p-Fluorofentanyl Analgesic activity Designer drug
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- 1.Blakeslee S (1985) California addicts use legal, synthetic narcotics. New York Times, March 24Google Scholar
- 2.Baum RM (1985) New variety of street drugs poses growing problem. Chem Eng News 63:7–16Google Scholar
- 3.Shafer J (1985) Designer drugs. Science 85(March):60–67Google Scholar
- 4.Stinson S (1981) Structure of bogus “China White” solved. Chem Eng News 59:71–72Google Scholar
- 7.Suzuki S, Inoue T, Kashima C (1986) Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and related compounds. I. Spectrometric and chromatographic analyses of 3-methylfentanyl and α-methylfentanyl. Chem Pharm Bull 34:1340–1343Google Scholar
- 8.Van Bever WFM, Niemegeers CJE, Janssen PAJ (1974) Synthetic analgesics. Synthesis and pharmacology of the diastereoisomers of N-[3-methyl-1-(2-phenylethyl)-4-piperidyl]-N-phenylpropanamide and N-[3-methyl-1-(1-methyl-2-phenylethyl)-4-piperidyl]-N-phenylpropanamide. J Med Chem 17:1047–1051PubMedCrossRefGoogle Scholar
- 9.Van Bever WFM, Niemegeer CJE, Schellkens KHL, Janssen PAJ (1976) N-4-Substituted 1-(2-arylethyl)-4-piperidinyl-N-phenylpropanamides, a novel series of extremely potent analgesics with unusually high safety margin. Arzneim-Forsch 26:1548–1551Google Scholar