Inhibitory activities of kukoamines A and B from Lycii Cortex on amyloid aggregation related to Alzheimer’s disease and type 2 diabetes
- 225 Downloads
Alzheimer’s diseases (AD) and type 2 diabetes (T2D) are two age-related diseases characterized by amyloid fibrillogenesis. Prevention of amyloid aggregation is a promising therapeutic strategy for AD and T2D. Two spermine alkaloids, kukoamines A and B, isolated from Lycii Cortex (LyC) were investigated for their inhibitory effect on amyloid aggregation. Both kukoamines A and B inhibited aggregation of amyloid β (Aβ) and human islet amyloid polypeptide (hIAPP) in a dose-dependent manner. Kukoamine B showed stronger inhibitory activity than kukoamine A. These results on the inhibitory activity of kukoamines A and B on Aβ and hIAPP indicate that the catechol moiety is essential for inhibition of amyloid aggregation.
KeywordsKukoamines A and B Lycii Cortex Amyloid aggregation Alzheimer’s disease Type 2 diabetes
We are pleased to acknowledge Professor Kazuhiro Irie, Associate Professor Kazuma Murakami, and Dr. Mizuho Hanaki, Graduate School of Agriculture, Kyoto University for preparing Aβ42. We would like to thank Editage (www.editage.jp) for English language editing. This work was partially supported by JSPS KAKENHI grant no. JP24580156.
Compliance with ethical standards
Conflict of interest
The authors declare no conflicts of interest.
- 9.Westermark P, Wernstedt C, Wilander E, Hayden DW, O’Brien TD, Johnson KH (1987) Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Proc Natl Acad Sci USA 84:3881–3885CrossRefPubMedGoogle Scholar
- 21.Yao X, Peng Y, Xu LJ, Li L, Wu QL, Xiao PG (2011) Phyto-chemical and biological studies of Lycium medicinal plants. Chem Bio Divers 8:976–1010Google Scholar