Two new alkaloids from Crinum asiaticum var. japonicum
- 46 Downloads
A new crinine-type alkaloid crijaponine A (1), a new galanthamine-type alkaloid crijaponine B (2), and 11 known alkaloids—ungeremine (3), lycorine (4), 2-O-acetyllycorine (5), 1, 2-O-diacetyllycorine (6), (−)-crinine (7), 11-hydroxyvittatine (8), hamayne (9), (+)-epibuphanisine (10), crinamine (11), yemenine A (12), and epinorgalanthamine (13)—were isolated from the rhizome and fruits of Crinum asiaticum var. japonicum. The structural elucidation of the isolated compounds was performed by spectroscopic methods including 2D NMR. The isolated compounds were evaluated for cytotoxicity against HeLa and HL-60 cells lines and were tested for acetylcholinesterase inhibition activity.
KeywordsCrinum asiaticum var. japonicum Crinine alkaloid Galanthamine alkaloid Cytotoxicity Acetylcholinesterase inhibitory activity
This work was supported by JSPS KAKENHI (Grant numbers 2410293, 16K01921 to AO). We are grateful to Mr. Kazuo Sugimura (Shimanto City Hall, Kochi Prefecture, Japan) for his support of the plant collection.
- 1.Lamoral-Theys D, Andolfi A, Goietsenoven GV, Cimmino A, Le Calvé B, Wauthoz N, Mégalizzi V, Gras T, Bruyère C, Dubois J, Mathieu V, Kornienko A, Kiss R, Evidente A (2009) Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure–activity relationship and mechanistic insight. J Med Chem 52:6244–6256CrossRefGoogle Scholar