Two new alkaloids from Crinum asiaticum var. japonicum

  • Yuta Endo
  • Yu Sugiura
  • Mariko Funasaki
  • Hiroyuki Kagechika
  • Masami Ishibashi
  • Ayumi OhsakiEmail author


A new crinine-type alkaloid crijaponine A (1), a new galanthamine-type alkaloid crijaponine B (2), and 11 known alkaloids—ungeremine (3), lycorine (4), 2-O-acetyllycorine (5), 1, 2-O-diacetyllycorine (6), (−)-crinine (7), 11-hydroxyvittatine (8), hamayne (9), (+)-epibuphanisine (10), crinamine (11), yemenine A (12), and epinorgalanthamine (13)—were isolated from the rhizome and fruits of Crinum asiaticum var. japonicum. The structural elucidation of the isolated compounds was performed by spectroscopic methods including 2D NMR. The isolated compounds were evaluated for cytotoxicity against HeLa and HL-60 cells lines and were tested for acetylcholinesterase inhibition activity.


Crinum asiaticum var. japonicum Crinine alkaloid Galanthamine alkaloid Cytotoxicity Acetylcholinesterase inhibitory activity 



This work was supported by JSPS KAKENHI (Grant numbers 2410293, 16K01921 to AO). We are grateful to Mr. Kazuo Sugimura (Shimanto City Hall, Kochi Prefecture, Japan) for his support of the plant collection.


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Copyright information

© The Japanese Society of Pharmacognosy 2019

Authors and Affiliations

  1. 1.College of Humanities and SciencesNihon UniversityTokyoJapan
  2. 2.Biomaterials and EngineeringTokyo Medical and Dental UniversityKandaJapan
  3. 3.Graduate School of Pharmaceutical SciencesChiba UniversityChibaJapan

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