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Mutagenetic and anti-allergic studies for evaluation of extracts of Coptis Rhizome produced by an artificial hydroponic system

  • Hiroshi AkiyamaEmail author
  • Mitsuhiko Nose
  • Hajime Takiguchi
  • Keiichi Sugiyama
  • Riho Tsutsui
  • Shinsuke Hisaka
  • Hiroyuki Fuchino
  • Takayuki Inui
  • Noriaki Kawano
  • Takaaki Taguchi
  • Tadashi Kudo
  • Nobuo Kawahara
  • Kayo Yoshimatsu
Note
  • 47 Downloads

Abstract

As a part of the investigation of the safety and efficacy of the cultivated Coptis japonica rhizome extracts using an artificial hydroponic cultivation system, the mutagenetic and anti-allergic activities were evaluated. Some extracts of commercial crude drugs of Coptis sp. were also evaluated for the comparison. None of the extracts showed a significant mutagenicity in Salmonella typhimurium TA102 by the Ames tests, but all the extracts showed in S. typhimurium TA98. The extracts of the hydroponically cultivated rhizomes showed anti-allergic activities against contact hypersensitivity as well as those of commercial crude drugs of Coptis sp. These results suggested the potential of the hydroponically cultivated rhizomes as one of the alternative sources for the medicinal usage.

Keywords

Coptis japonica Berberine Hydroponic cultivation 

Notes

Acknowledgements

This study was supported by a Health and Labour Sciences Research Grant from the Ministry of Health, Labour and Welfare of Japan, a Grant from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The authors would like to thank the Japan Kampo Medicines Manufacturers Association and Tokyo Crude Drug Association for providing the commercial Coptis crude drugs.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Supplementary material

11418_2019_1288_MOESM1_ESM.docx (1.2 mb)
Supplementary material 1 (DOCX 1245 kb)

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Copyright information

© The Japanese Society of Pharmacognosy 2019

Authors and Affiliations

  • Hiroshi Akiyama
    • 1
    Email author
  • Mitsuhiko Nose
    • 2
  • Hajime Takiguchi
    • 1
  • Keiichi Sugiyama
    • 1
  • Riho Tsutsui
    • 2
  • Shinsuke Hisaka
    • 2
  • Hiroyuki Fuchino
    • 3
  • Takayuki Inui
    • 3
  • Noriaki Kawano
    • 3
  • Takaaki Taguchi
    • 1
  • Tadashi Kudo
    • 4
  • Nobuo Kawahara
    • 3
  • Kayo Yoshimatsu
    • 3
  1. 1.National Institute of Health SciencesKanagawaJapan
  2. 2.Faculty of PharmacyMeijo UniversityTempakuJapan
  3. 3.Tsukuba Division, Research Center for Medicinal Plant ResourcesNational Institutes of Biomedical Innovation, Health and NutritionTsukubaJapan
  4. 4.Kajima Technical Research Institute, Kajima CorporationChofushiJapan

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