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Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells

  • Kazumi Sagayama
  • Naonobu Tanaka
  • Takatoshi Fukumoto
  • Yoshiki KashiwadaEmail author
Note
  • 34 Downloads

Abstract

Chaga mushrooms, the sclerotium of Inonotus obliquus, have been used in Mongolia as a traditional hair shampoo to maintain healthy hair. Bioassay-guided fractionations of the extract of Chaga mushrooms using a proliferation assay on human follicle dermal papilla cells (HFDPCs) gave five lanostane-type triterpenes (1–5), whose structures were identified by spectroscopic evidence. Among these, lanosterol (1), inotodiol (3), lanost-8,24-diene-3β,21-diol (4), and trametenolic acid (5) demonstrated proproliferative effects on HFDPCs more potent than minoxidil, an anti-alopecia agent, used as the positive control. The lanostane-type triterpenes (1, 3, 4, and 5) appeared to be potential candidates of new agents possibly used for hair-care with a stimulative effect on hair growth.

Keywords

Inonotus obliquus Chaga mushroom Lanostane-type triterpene Hair growth Human follicle dermal papilla cell 

Notes

Acknowledgements

This study was partly supported by JSPS KAKENHI Grant numbers JP22406024 and JP26305003, and by SVENSON Co., Ltd., Tokyo, Japan.

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Copyright information

© The Japanese Society of Pharmacognosy 2019

Authors and Affiliations

  • Kazumi Sagayama
    • 1
  • Naonobu Tanaka
    • 1
    • 2
  • Takatoshi Fukumoto
    • 3
  • Yoshiki Kashiwada
    • 1
    Email author
  1. 1.Graduate School of Pharmaceutical SciencesTokushima UniversityTokushimaJapan
  2. 2.Graduate School of Technology, Industrial and Social SciencesTokushima UniversityTokushimaJapan
  3. 3.SVENSON Co., Ltd.TokyoJapan

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