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Journal of Natural Medicines

, Volume 73, Issue 1, pp 210–216 | Cite as

Caryopincaolide M, a rearranged abietane diterpenoid with new skeleton and a new iridoid from Caryopteris incana

  • Cheng-Gang Zhang
  • Ting Chen
  • Xu-Dong Mao
  • Sen-Miao Zhao
  • Gui-Xin ChouEmail author
Original Paper
  • 107 Downloads

Abstract

Caryopincaolide M (1), a new rearranged abietane diterpenoid with an unusual pent-4-enoic acid group on a 6/6/5 tricyclic ring system, and 7-epi-8-dehydroxypatriscabrol (3), a new iridoid, together with 17 known compounds, have been isolated from the whole plant of Caryopteris incana (Thunb.) Miq. Their structures were elucidated on the basis of 1-D and 2-D NMR, IR, and mass spectroscopic data. Compounds 1–5 were evaluated for their inhibitory activities against enzyme α-glucosidase, and the results showed that only 1 has moderate inhibitory activity against enzyme α-glucosidase with IC50 at 528.3 ± 12.37 mg/L.

Keywords

Caryopteris incana Diterpenoid Iridoid α-glucosidase 

Notes

Acknowledgement

Financial support from the National Nature Science Foundation of China (No. 21672152) is gratefully acknowledged.

Supplementary material

11418_2018_1268_MOESM1_ESM.docx (1.3 mb)
Supplementary material 1 (DOCX 1344 kb)

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Cheng-Gang Zhang
    • 1
    • 2
    • 3
  • Ting Chen
    • 1
    • 2
  • Xu-Dong Mao
    • 1
    • 2
  • Sen-Miao Zhao
    • 1
    • 2
  • Gui-Xin Chou
    • 1
    • 2
    Email author
  1. 1.The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghaiChina
  2. 2.Shanghai R&D Center for Standardization of Chinese MedicinesShanghaiChina
  3. 3.Guiyang University of Chinese MedicineGuiyangChina

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