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Journal of Natural Medicines

, Volume 73, Issue 1, pp 289–296 | Cite as

Structure of constituents isolated from the bark of Cassipourea malosana and their cytotoxicity against a human ovarian cell line

  • Yumi NishiyamaEmail author
  • Yuki Noda
  • Noriyoshi Nakatani
  • Nobukazu Shitan
  • Tamotsu Sudo
  • Atsushi Kato
  • Patrick B. Chalo Mutiso
Note
  • 166 Downloads

Abstract

Three aromatic compounds, 2α,3α-epoxyflavan-5,7,4′-triol-(4β → 8)-afzelechin (1), 2β,3β-epoxyflavan-5,7,4′-triol-(4α → 8)-epiafzelechin (2), and methyl 4-ethoxy-2-hydroxy-6-propylbenzoate (3), as well as eight known compounds (411) were isolated from the bark of Cassipourea malosana (Rhizophoraceae). Their structures were determined on the basis of an analysis of spectroscopic data. The in vitro cytotoxic activities of these compounds against human ovarian cancer cell line TOV21G were evaluated. Most compounds showed little activity; however, the methyl derivatives of flavan dimers (1a and 2a) showed higher activity (IC50 value of 30.3 and 75.4 μM) than parent compounds 1 and 2.

Keywords

Cassipourea malosana Rhizophoraceae Flavan dimer Ovarian cancer cell 

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Medicinal Cell BiologyKobe Pharmaceutical UniversityKobeJapan
  2. 2.Hyogo Cancer CenterAkashiJapan
  3. 3.Department of BotanyUniversity of NairobiNairobiKenya

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