Journal of Natural Medicines

, Volume 73, Issue 1, pp 1–10 | Cite as

A review of the ethnopharmacology, phytochemistry, and pharmacology of Changium smyrnioides Wolff

  • Lu-Jing Lei
  • Wen-Le Wang
  • Jie Wang
  • Li-juan Lv
  • Min-Hui LiEmail author


Changium smyrnioides Wolff is a monotypic species of the genus Changium Wolff which is only found in eastern China. C. smyrnioides has been used as a traditional medicine for ages to treat cough, vomiting, nausea, megrim, and carbuncle. It is also widely used to brew medicated liquor and health tea with other herbs in order to moisten the lungs and nourish blood and yin. This review comprehensively summarizes the up-to-date information on the botanical characterization, distribution, traditional uses, ethnopharmacology, phytochemistry, pharmacology, and toxicity of C. smyrnioides based on studies published in recent years. Phytochemical investigations have revealed that phenylpropanoids, volatile oils, fatty acids, phytosterols, and other bioactive compounds are contained in C. smyrnioides. Crude extracts and monomeric compounds isolated from C. smyrnioides have significant effects on the respiratory, immune, and vascular systems and exhibit favourable activities such as antitussive, eliminating phlegm, anti-asthmatic, immunoregulatory, antioxidant, anti-tumor, anti-fatigue, anti-hypoxia, and anti-atherosclerotic effects. C. smyrnioides is a promising medicinal herb with immense therapeutic and health-promoting effects. Therefore, further studies on the bioactive compounds and mechanisms of C. smyrnioides are necessary. Additional clinical and toxicological studies are warranted to evaluate its safety.


Changium smyrnioides Wolff Ethnopharmacology Phytochemistry Pharmacology 



This study was supported by a grant (ZYY-2017-069) for the TCM (Traditional Chinese Medicine) Standardization Project from State Administration of TCM and Tianjin Applied Foundation and Frontier Technology Research Program (15JCQNJC13400). We thank professor Hua-Sheng Peng for providing the images of C. smyrnioides.


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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Lu-Jing Lei
    • 1
  • Wen-Le Wang
    • 1
  • Jie Wang
    • 3
  • Li-juan Lv
    • 4
  • Min-Hui Li
    • 1
    • 2
    • 3
    Email author
  1. 1.Inner Mongolia Institute of Traditional Chinese MedicineHohhotChina
  2. 2.Guangxi Key Laboratory of Medicinal Resources Protection and Genetic ImprovementGuangxi Botanical Garden of Medicinal PlantsNanningChina
  3. 3.Baotou Medical CollegeBaotouChina
  4. 4.Department of Basic ScienceTianjin Agricultural UniversityTianjinChina

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