Journal of Natural Medicines

, Volume 73, Issue 1, pp 252–256 | Cite as

Two new oleanane derivatives from the fruits of Leonurus japonicus and their cytotoxic activities

  • Wenwen PengEmail author
  • Guanghu Huo
  • Lixia Zheng
  • Zhonghua Xiong
  • Xugen Shi
  • Dayong Peng


Two new oleanane derivatives, leonuronins A and B (1 and 2), along with three known oleanane triterpenes (35) were isolated from the fruits of Leonurus japonicus. Their structures were elucidated on the basis of NMR, MS, IR and UV spectroscopic data. The new compounds were tested for cytotoxic activities against A549 and Hela cancer cell lines. Compounds 1 and 2 exhibited weak cytotoxicity with IC50 values ranging from 6.97 to 18.13 μM.


Leonurus japonicus Oleanane triterpenes Cytotoxic activities A549 HeLa 



This work was financially supported by the Funds of NSFC-Jiangxi Province (No. 20161BAB204179), Jiangxi provincial education office (No. GJJ150407), and Post Doctoral in Jiangxi (No. 06292023).

Compliance with ethical standards

Conflict of interest

The authors indicate that there is no conflict of interest.


  1. 1.
    The Editorial Board of Flora of China (1977) Flora of China. Science Press, Beijing, pp 505–511Google Scholar
  2. 2.
    Hu SY (1976) A contribution to our knowledge of Leonurus L., I-mu-ts’ao, the Chinese motherwort. Am J Chin Med 4:219–237CrossRefGoogle Scholar
  3. 3.
    Ye M, Xiong J, Zhu JJ, Hong JL, Zhao Y, Fan H, Yang GX, Xia G, Hu JF (2014) Leonurusoleanolides E–J, minor spirocyclic triterpenoids from Leonurus japonicus fruits. J Nat Prod 77:178–182CrossRefGoogle Scholar
  4. 4.
    Liu Y, Kubo M, Fukuyama Y (2012) Spirocyclic nortriterpenoids with NGF-potentiating activity from the fruits of Leonurus heterophyllus. J Nat Prod 75:1353–1358CrossRefGoogle Scholar
  5. 5.
    Zheng YQ, Yan H, Han J, Tan NH (2012) A new C-28 nortriterpenoid from fruits of Leonurus japonicus. China J Chin Mater Med 37:2088–2091Google Scholar
  6. 6.
    Song YL, Wang YH, Lu Q, Qiao HJ, Cheng YX (2008) Triterpenoids from the edible leaves of Photinia serrulata. Helv Chim Acta 91:665–672CrossRefGoogle Scholar
  7. 7.
    Wu ZF, Meng FC, Cao LJ, Jiang CH, Zhao MG, Shang XL, Fang SZ, Ye WC, Zhang QW, Zhang J, Yin ZQ (2017) Triterpenoids from Cyclocarya paliurus and their inhibitory effect on the secretion of apoliprotein B48 in Caco-2 cells. Phytochemistry 142:76–84CrossRefGoogle Scholar
  8. 8.
    Song B, Zhang QB, Wang MH, Tian XH, Sun HL, Zhang FB, Zou ZM, Ding G (2015) Chemical investigation of triterpenoids from Dichrocephala benthamii. China J Chin Mater Med 40:2144–2147Google Scholar
  9. 9.
    Kim KH, Choi SU, Lee KR (2010) Bioactivity-guided isolation of cytotoxic triterpenoids from the trunk of Berberis koreana. Bioorg Med Chem Lett 20:1944–1947CrossRefGoogle Scholar
  10. 10.
    Lee CK (1998) Ursane triterpenoids from leaves of Melaleuca leucadendron. Phytochemistry 49:1119–1122CrossRefGoogle Scholar
  11. 11.
    Fourie TG, Snyckers FO (1989) A pentacyclic triterpene with anti-inflammatory and analgesic activity from the roots of Commiphora merkeri. J Nat Prod 51:1129–1131CrossRefGoogle Scholar
  12. 12.
    Peng WW, Zeng GZ, Song WW, Tan NH (2013) A new cytotoxic carbazole alkaloid and two new other alkaloids from Clausena excavata. Chem Biodivers 10:1317–1321CrossRefGoogle Scholar

Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Wenwen Peng
    • 1
    • 2
    • 3
    Email author
  • Guanghu Huo
    • 1
  • Lixia Zheng
    • 3
  • Zhonghua Xiong
    • 3
  • Xugen Shi
    • 3
  • Dayong Peng
    • 2
  1. 1.Jiangxi Key Laboratory for Conservation and Utilization of Fungal ResourcesJiangxi Agricultural UniversityNanchangChina
  2. 2.Jiangxi Key Laboratory of Natural Products and Functional FoodJiangxi Agricultural UniversityNanchangChina
  3. 3.College of AgricultureJiangxi Agricultural UniversityNanchangChina

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