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Journal of Natural Medicines

, Volume 73, Issue 1, pp 23–33 | Cite as

Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii

  • Dongsheng Fan
  • Ting Li
  • Zhiyuan Zheng
  • Guo-Yuan Zhu
  • Xiaojun Yao
  • Zhi-Hong Jiang
  • Li-Ping Bai
Original Paper
  • 84 Downloads

Abstract

Nine new monomacrolide sesquiterpene pyridine alkaloids, macroregelines A–I (19), were isolated from the stems of Tripterygium regelii, along with a known alkaloid, tripfordine B. The structures of all the isolated compounds were characterized by extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopic analyses, as well as high-resolution electrospray-ionization mass spectrometry (HRESIMS) data. Compounds 4, 5, 6, and 8 showed antiproliferative effect on human rheumatoid arthritis synovial cell line MH7A at concentration of 20 μM, reducing their viability by 7.5, 18.0, 9.0, and 18.2 %, respectively.

Keywords

Tripterygium regelii Monomacrolide sesquiterpene pyridine alkaloids Antiinflammation 

Notes

Acknowledgements

This research work was financially supported by Macao Science and Technology Development Fund (grant no. 056/2013/A2 and 063/2011/A3).

Supplementary material

11418_2018_1232_MOESM1_ESM.pdf (7.4 mb)
Supplementary material 1 (PDF 7555 kb)

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  1. 1.State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and HealthMacau University of Science and TechnologyTaipaChina
  2. 2.The First Affiliated Hospital of Guiyang University of Chinese MedicineGuiyang University of Chinese MedicineGuiyangChina

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